ERCC6

ERCC excision repair 6, chromatin remodeling factor

Explore in graph →CI-GENE-00044920HGNC:3438 ENSG00000225830 NCBI 2074 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ERCC6 Overexpression1
Fluorouracil	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	D	Supports Resistance	3	submitted	EID12121 ERCC6 was knocked down using shRNA in HCT116 and DLD1 human colorectal cancer (CRC) cell lines, which made both cell lines more sensitive to 5-FU. To assess whether ERCC6 influences chemosensitivity i… (full text at CIViC) PMID 28665687 · Zhao et al., 2017 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (3)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved3 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Small-Cell Lung Cancer (Multi-Institute, Cancer Cell 2017) sclc_cancercell_gardner_2017	Lung Small Cell Carcinoma	Ssm	16

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.