EPHB2 — gene · CancerIndex

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
EPHB2 D679N (c.2035G>A)1
(diagnostic)	Malignant Prostate Neoplasm	Diagnostic	B	Supports Positive	3	submitted	EID7230 The identification of tumor-suppressor genes in solid tumors by classical cancer genetics methods is difficult and slow. Nonsense-mediated RNA decay microarrays were combined with array-based compara… (full text at CIViC) PMID 15300251 · Huusko et al., 2004 · Open in CIViC	civic
EPHB2 EPHB21
(diagnostic)	Malignant Prostate Neoplasm	Diagnostic	B	Supports Positive	3	submitted	EID7226 The EphB2 gene has been implicated as a tumor suppressor gene somatically altered in both prostate cancer (PC) and colorectal cancer. A set of 341 single nucleotide polymorphisms (SNPs) encompassing … (full text at CIViC) PMID 21603658 ·

Cohorts

Alteration frequency by cohort (9)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved9 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Kidney Renal Clear Cell Carcinoma (IRC, Nat Genet 2014) ccrcc_irc_2014	Clear Cell Renal Cell Carcinoma	Ssm	8

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.