Gene

DDX3X

DEAD-box helicase 3 X-linked

Explore in graph →CI-GENE-00043067HGNC:2745 ENSG00000215301 NCBI 1654 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
DDX3X D347G1
(oncogenic)	Burkitt Lymphoma	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11812 DDX3X mutations are one of the most common somatic alterations in BL. This is just an arbitrarily chosen example of a mutation observed in the cited study. PMID 30617194 · Grande et al., 2019 · Open in CIViC	civic
DDX3X Mutation1
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11940 Identified from exome sequencing of 574 DLBCL biopsies PMID 29641966 · Schmitz et al., 2018 · Open in CIViC

Cohorts

Alteration frequency by cohort (36)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved36 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Mature B-Cell Neoplasms (Simon Fraser University, Blood 2023) mbn_sfu_2023	B-Cell Non-Hodgkin Lymphoma	Ssm	124

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.