Gene
COP1
COP1 E3 ubiquitin ligase
Explore in graph →CI-GENE-00041927HGNC:17440 ENSG00000143207 NCBI 64326 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (73)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 29122777
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Metastatic Esophagogastric Cancer (MSK, Cancer Discovery 2017) egc_msk_2017 | Gastroesophageal Junction Adenocarcinoma | Ssm | 3 | 333 | 0.9% | 183 | cbioportal |
| Pediatric Neuroblastoma (MSK, Nat Genet 2023) nbl_msk_2023 | Neuroblastoma | Ssm | 2 | 222 | 0.9% | 61 | cbioportal |
| HER2-Low and HER2-Null Metastatic Breast Cancers treated with T-DXd (MSK, Clinical Cancer Research 2026) brca_msk_erbb2_2026 | unmapped | Ssm | 2 | 231 | 0.9% | 149 | cbioportal |
| Gallbladder Cancer (MSK, 2022) gbc_mskcc_2022 | Gallbladder Carcinoma | Ssm | 2 | 244 | 0.8% | 175 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.