Gene
CIC
capicua transcriptional repressor
Explore in graph →CI-GENE-00041374HGNC:14214 ENSG00000079432 NCBI 23152 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (11)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28178529
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CIC Loss9 | ||||||||
| Selumetinib | Malignant Pancreatic Neoplasm | Predictive | D | Supports Resistance | 3 | submitted | EID5115CIC knockout conferred resistance to selumetinib in KRAS G12V (PATU8902) pancreatic cancer cells. | |
Cohorts
Alteration frequency by cohort (158)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 40511613
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Pancreatic Cancer cfDNA (MSK, J Natl Cancer Inst 2025) pancreas_ctdna_msk_2025 | Pancreatic Adenocarcinoma | Ssm |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.