CIC R201W

CI-VAR-00003756Explore in graph →CIViC 4305

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
CIC R201W	(functional)	Functional	D	Supports Loss Of Function	2	submitted	EID11029 The cooperation of IDH1 R132H and CIC R201W mutations were evaluated in HOG and HEK cell lines transfected with wildtype and mutant forms. In the IDH1-R132H background, 2KG metabolite levels were incr… (full text at CIViC) PMID 25277207 · Chittaranjan et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.