Gene

CCDC170

coiled-coil domain containing 170

Explore in graph →CI-GENE-00040274HGNC:21177 ENSG00000120262 NCBI 80129 Approved

Curated evidence

Clinical evidence (5)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CCDC170 Fusion5
Dasatinib + FulvestrantCombination	Malignant Breast Neoplasm	Predictive	D	Supports Sensitivity Response	3	submitted	EID11514 Protein-based assays showed that ESR1::CCDC170 fusion expressing cells had increased protein expression of HER2 and SRC, as well as increased HER2 phosphorylation. The ESR1::CCDC170 fusion, E2-E7 and … (full text at CIViC) PMID 32771039 · Li et al., 2020 · Open in CIViC	civic
Fulvestrant + LapatinibCombination	Malignant Breast Neoplasm	Predictive	D	Supports Sensitivity Response	3	submitted	EID11513 Protein-based assays showed that ESR1::CCDC170 fusion expressing cells had increased protein expression of HER2 and SRC, as well as increased HER2 phosphorylation. The ESR1::CCDC170 fusion, E2-E7 and …

Cohorts

Alteration frequency by cohort (6)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved6 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Squamous Cell Carcinoma of the Vulva (CUK, Exp Mol Med 2018) vsc_cuk_2018	Vaginal Squamous Cell Carcinoma, Not Otherwise Specified	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.