CCDC170 Fusion

CI-VAR-00001376Explore in graph →CIViC 4553

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Breast Neoplasm5
ESR1::CCDC170 Fusion	Dasatinib + FulvestrantCombination	Predictive	D	Supports Sensitivity Response	3	submitted	EID11514 Protein-based assays showed that ESR1::CCDC170 fusion expressing cells had increased protein expression of HER2 and SRC, as well as increased HER2 phosphorylation. The ESR1::CCDC170 fusion, E2-E7 and … (full text at CIViC) PMID 32771039 · Li et al., 2020 · Open in CIViC	civic
ESR1::CCDC170 Fusion	Fulvestrant + LapatinibCombination	Predictive	D	Supports Sensitivity Response	3	submitted	EID11513 Protein-based assays showed that ESR1::CCDC170 fusion expressing cells had increased protein expression of HER2 and SRC, as well as increased HER2 phosphorylation. The ESR1::CCDC170 fusion, E2-E7 and … (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.