Gene

AXIN2

axin 2

Explore in graph →CI-GENE-00021504HGNC:904 ENSG00000168646 NCBI 8313 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
AXIN2 rs1433488531
(predisposing)	Chronic Lymphocytic Leukemia	Predisposing	A	Supports Protectiveness	5	submitted	EID12065 The germline variant rs143348853 (5bp deletion), creates MEF2 transcription factor binding site, which induces activity in the locus around AXIN2 gene and associates with elevated AXIN2 expression. In… (full text at CIViC) PMID 35440565 · Llimos et al., 2022 · Open in CIViC	civic
AXIN2 P455K + BAX L76R + BRAF V600E + CDKN2A Deletion + CDKN2B Deletion + TET2 E796KCDKN2B TET2 BAX AXIN2 BRAF CDKN2A1
Cobimetinib + VemurafenibCombination

Cohorts

Alteration frequency by cohort (115)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved115 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Esophageal/Stomach Cancer (MSK, 2020) egc_mskcc_2020	unmapped	Ssm	11	487	2.3%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.