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Drugs
One entity per molecule (INN preferred); brand names and development codes are aliases. Approvals are always shown with jurisdiction and indication.
820 drugs
| Drug | Kind | Mechanism | Approvals | Evidence items | Trials | Identifiers |
|---|---|---|---|---|---|---|
| Lifileucel | Cell Therapy | Somatic cell supplemental therapy | 1 | 0 | 29 | CHEMBL4298200 |
| Linvoseltamab | Monoclonal Antibody | — | 1 | 0 | 20 | CHEMBL5095373 |
| Melphalan Flufenamide | Small Molecule | DNA cross-linking agent | 1 | 0 | 9 | CHEMBL4303060 |
| Methyl Aminolevulinate | Small Molecule | DNA inhibitor | 1 | 0 | 14 | CHEMBL1096562 |
| Mifamurtide | Small Molecule | Nucleotide-binding oligomerization domain-containing protein 2 other | 1 | 0 | 6 | CHEMBL2107354 |
| Moxetumomab Pasudotox | Adc | CD22 binding agent; Elongation factor 2 inhibitor | 1 | 0 | 8 | CHEMBL1743043 |
| Obecabtagene Autoleucel | Gene Therapy | B-lymphocyte antigen CD19 binding agent | 1 | 0 | 4 | CHEMBL5095440 |
| Odronextamab | Monoclonal Antibody | B-lymphocyte antigen CD20 binding agent; T cell surface glycoprotein CD3 binding agent | 1 | 0 | 14 | CHEMBL4298084 |
| Padeliporfin | Small Molecule | Vascular targeted photodynamic therapy | 1 | 0 | 5 | CHEMBL4594284 |
| Pimicotinib | Small Molecule | — | 1 | 0 | 4 | CHEMBL5314535 |
| Pixantrone Dimaleate | Small Molecule | DNA cross-linking agent | 1 | 0 | 4 | CHEMBL2103844 |
| Radium Ra223 dichloride | Small Molecule | Radiotherapy agent | 1 | 0 | 0 | CHEMBL2107816 |
| Ruxolitinib Hemifumarate | — | — | 1 | 0 | 0 | — |
| Serplulimab | Monoclonal Antibody | Programmed cell death protein 1 antagonist | 1 | 0 | 97 | CHEMBL4594550 |
| Streptozocin | Small Molecule | DNA inhibitor | 1 | 0 | 7 | CHEMBL1977579 |
| Sugemalimab | Monoclonal Antibody | Programmed cell death 1 ligand 1 binding agent | 1 | 0 | 12 | CHEMBL4594535 |
| Talimogene Laherparepvec | Gene Therapy | Melanoma cell disrupting agent | 1 | 0 | 43 | CHEMBL2108727 |
| Temoporfin | Small Molecule | Photosensitizer | 1 | 0 | 8 | CHEMBL500576 |
| Teniposide | Small Molecule | DNA topoisomerase II inhibitor | 1 | 0 | 14 | CHEMBL452231 |
| Tositumomab | Monoclonal Antibody | B-lymphocyte antigen CD20 binding agent | 1 | 0 | 3 | CHEMBL1201604 |
| Vindesine | Small Molecule | — | 1 | 0 | 36 | CHEMBL238071 |
| Vinflunine | Small Molecule | Tubulin inhibitor | 1 | 0 | 26 | CHEMBL2110725 |
| Yttrium-90 | Small Molecule | — | 1 | 0 | 1 | CHEMBL4650364 |
| Chemotherapy | — | — | 0 | 61 | 618 | C15632 |
| Dactolisib | Small Molecule | Serine/threonine-protein kinase mTOR inhibitor; PI3-kinase class I inhibitor | 0 | 53 | 16 | C74072 · CHEMBL1879463 |
| Regorafenib Anhydrous | Small Molecule | Tyrosine-protein kinase ABL inhibitor; Serine/threonine-protein kinase RAF inhibitor; Stem cell growth factor receptor inhibitor; Fibroblast growth factor receptor 1 inhibitor; MAP kinase p38 beta inhibitor; Fibroblast growth factor receptor 2 inhibitor; Tyrosine-protein kinase FRK inhibitor; Discoidin domain-containing receptor 2 inhibitor; Serine/threonine-protein kinase B-raf inhibitor; Tyrosine-protein kinase TIE-2 inhibitor; Platelet-derived growth factor receptor inhibitor; Vascular endothelial growth factor receptor inhibitor; Tyrosine-protein kinase receptor RET inhibitor; Ephrin type-A receptor 2 inhibitor; Nerve growth factor receptor Trk-A inhibitor | 0 | 43 | 0 | C78204 · CHEMBL1946170 |
| Pictilisib | Small Molecule | PI3-kinase class I inhibitor | 0 | 26 | 11 | C165479 · CHEMBL521851 |
| MDM2 Inhibitor AMGMDS3 | — | — | 0 | 23 | 0 | C171616 |
| Crenolanib | Small Molecule | Platelet-derived growth factor receptor inhibitor; Tyrosine-protein kinase receptor FLT3 inhibitor | 0 | 22 | 18 | C64639 · CHEMBL2105728 |
| BRAF Inhibitor | — | — | 0 | 21 | 2 | C155322 |
| Aspirin | Small Molecule | Cyclooxygenase inhibitor | 0 | 19 | 125 | C287 · CHEMBL25 |
| Immune Checkpoint Inhibitor | — | — | 0 | 18 | 32 | C143250 |
| Mitogen-Activated Protein Kinase Kinase Inhibitor | — | — | 0 | 17 | 0 | C69145 |
| Lestaurtinib | Small Molecule | Tyrosine-protein kinase receptor FLT3 inhibitor; Tyrosine-protein kinase JAK2 inhibitor; Nerve growth factor receptor Trk-A inhibitor; Neurotrophic tyrosine kinase receptor type 2 inhibitor; NT-3 growth factor receptor inhibitor; Tyrosine-protein kinase receptor RET inhibitor | 0 | 16 | 7 | C48402 · CHEMBL603469 |
| PI103 | — | — | 0 | 16 | 0 | — |
| ALK Inhibitor TAE684 | — | — | 0 | 15 | 0 | C171615 |
| Platinum Compound | — | — | 0 | 15 | 2 | C1450 |
| Bafetinib | Small Molecule | Tyrosine-protein kinase ABL inhibitor; Tyrosine-protein kinase Lyn inhibitor | 0 | 14 | 4 | C62516 · CHEMBL206834 |
| Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor | — | — | 0 | 14 | 1 | C2167 |
| Dovitinib | Small Molecule | Fibroblast growth factor receptor 3 inhibitor; Tyrosine-protein kinase receptor FLT3 inhibitor; Stem cell growth factor receptor inhibitor; Platelet-derived growth factor receptor inhibitor; Vascular endothelial growth factor receptor inhibitor | 0 | 13 | 35 | C76199 · CHEMBL522892 |
| Belvarafenib | Small Molecule | RAF serine/threonine protein kinase inhibitor | 0 | 11 | 6 | C121646 · CHEMBL3977543 |
| Fexagratinib | Small Molecule | Fibroblast growth factor receptor inhibitor | 0 | 11 | 16 | C88272 · CHEMBL3348846 |
| PD173074 | — | — | 0 | 11 | 0 | — |
| Akt Inhibitor MK2206 | — | — | 0 | 10 | 45 | C90581 |
| PLX4720 | — | — | 0 | 10 | 0 | — |
| R3Mab | — | — | 0 | 10 | 0 | — |
| JQ1 | Small Molecule | — | 0 | 9 | 0 | CHEMBL1957266 |
| PI3Ka/Di | — | — | 0 | 9 | 0 | — |
| GSK126 | — | — | 0 | 8 | 0 | — |
| Linsitinib | Small Molecule | Insulin-like growth factor I receptor inhibitor; Insulin receptor inhibitor | 0 | 8 | 20 | C70982 · CHEMBL1091644 |