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Drugs
One entity per molecule (INN preferred); brand names and development codes are aliases. Approvals are always shown with jurisdiction and indication.
820 drugs
| Drug | Kind | Mechanism | Approvals | Evidence items | Trials | Identifiers |
|---|---|---|---|---|---|---|
| Imlunestrant | Small Molecule | — | 2 | 0 | 10 | CHEMBL5095183 |
| Interferon Alpha-N1 | — | — | 2 | 0 | 0 | — |
| Leniolisib | Small Molecule | PI3-kinase p110-delta subunit inhibitor | 2 | 0 | 0 | CHEMBL3643413 |
| Lisocabtagene Maraleucel | Gene Therapy | B-lymphocyte antigen CD19 binding agent | 2 | 0 | 23 | CHEMBL4297236 |
| Lutetium (177lu) Oxodotreotide | Other | Somatostatin receptor binding agent | 2 | 0 | 36 | CHEMBL4297545 |
| Lutetium (177lu) Vipivotide Tetraxetan | Other | Glutamate carboxypeptidase II binding agent; DNA disrupting agent | 2 | 0 | 43 | CHEMBL4594406 |
| Mechlorethamine | Small Molecule | DNA inhibitor | 2 | 0 | 15 | CHEMBL427 |
| Nadofaragene Firadenovec | Gene Therapy | Interferon alpha-2 exogenous gene | 2 | 0 | 10 | CHEMBL3990041 |
| Necitumumab | Monoclonal Antibody | Epidermal growth factor receptor erbB1 inhibitor | 2 | 0 | 21 | CHEMBL1743047 |
| Nogapendekin Alfa Inbakicept | Other | Interleukin-15 receptor agonist | 2 | 0 | 6 | CHEMBL6068330 |
| Procarbazine | Small Molecule | DNA inhibitor | 2 | 0 | 57 | CHEMBL1321 |
| Radium Ra-223 Dichloride | Small Molecule | Radiotherapy agent | 2 | 0 | 5 | CHEMBL2107816 |
| Tivozanib | Small Molecule | Vascular endothelial growth factor receptor inhibitor; Stem cell growth factor receptor inhibitor; Platelet-derived growth factor receptor beta inhibitor | 2 | 0 | 31 | CHEMBL1289494 |
| Toremifene | Small Molecule | Estrogen receptor modulator | 2 | 0 | 23 | CHEMBL1655 |
| Dacomitinib | Small Molecule | Epidermal growth factor receptor erbB1 inhibitor; Receptor protein-tyrosine kinase erbB-2 inhibitor; Receptor protein-tyrosine kinase erbB-4 inhibitor | 1 | 16 | 17 | C53398 · CHEMBL2105719 |
| Prednisone | Small Molecule | Glucocorticoid receptor agonist | 1 | 12 | 834 | C770 · CHEMBL635 |
| Mirdametinib | Small Molecule | Dual specificity mitogen-activated protein kinase kinase 1 inhibitor; Dual specificity mitogen-activated protein kinase kinase 2 inhibitor | 1 | 11 | 21 | C52195 · CHEMBL507361 |
| Panobinostat | Small Molecule | Histone deacetylase inhibitor | 1 | 8 | 119 | C66948 · CHEMBL483254 |
| Pacritinib | Small Molecule | Tyrosine-protein kinase JAK2 inhibitor; Tyrosine-protein kinase receptor FLT3 inhibitor; Activin receptor type-1 inhibitor; Interleukin-1 receptor-associated kinase 1 inhibitor | 1 | 6 | 36 | C78837 · CHEMBL2035187 |
| Dordaviprone | Small Molecule | Unknown | 1 | 4 | 29 | C113792 · CHEMBL4297310 |
| Olutasidenib | Small Molecule | Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | 1 | 4 | 14 | C129687 · CHEMBL4297610 |
| Ensartinib | Small Molecule | ALK tyrosine kinase receptor inhibitor | 1 | 3 | 24 | C102754 · CHEMBL4113131 |
| Tegafur | Small Molecule | RNA inhibitor; Thymidylate synthase inhibitor; DNA inhibitor | 1 | 3 | 38 | C513 · CHEMBL20883 |
| Teprotumumab | Monoclonal Antibody | Insulin-like growth factor I receptor antagonist | 1 | 3 | 9 | C95797 · CHEMBL1743079 |
| Aumolertinib | Small Molecule | Epidermal growth factor receptor erbB1 inhibitor | 1 | 2 | 44 | C133691 · CHEMBL4761468 |
| Belinostat | Small Molecule | Histone deacetylase inhibitor | 1 | 2 | 49 | C48812 · CHEMBL408513 |
| Levoleucovorin | Small Molecule | Unknown | 1 | 2 | 39 | C1559 · CHEMBL1908841 |
| Sulindac | Small Molecule | Cyclooxygenase inhibitor | 1 | 2 | 22 | C850 · CHEMBL15770 |
| Taletrectinib | Small Molecule | Proto-oncogene tyrosine-protein kinase ROS inhibitor; Neurotrophic tyrosine kinase receptor inhibitor | 1 | 2 | 10 | C118948 · CHEMBL4650989 |
| Valproic Acid | Small Molecule | Succinate semialdehyde dehydrogenase inhibitor | 1 | 2 | 57 | C29536 · CHEMBL109 |
| Ziftomenib | Small Molecule | — | 1 | 2 | 16 | C164227 · CHEMBL5095038 |
| Aminoglutethimide | Small Molecule | Cytochrome P450 19A1 inhibitor; Cytochrome P450 11A1 inhibitor | 1 | 1 | 1 | C233 · CHEMBL488 |
| Amphotericin B | Small Molecule | Ergosterol sequestering agent | 1 | 1 | 4 | C238 · CHEMBL267345 |
| Chloroquine | Small Molecule | Ferriprotoporphyrin IX inhibitor; Ferriprotoporphyrin IX binding agent | 1 | 1 | 14 | C61671 · CHEMBL76 |
| Dacomitinib | Small Molecule | Epidermal growth factor receptor erbB1 inhibitor; Receptor protein-tyrosine kinase erbB-2 inhibitor; Receptor protein-tyrosine kinase erbB-4 inhibitor | 1 | 1 | 0 | C95799 · CHEMBL2105719 |
| Lonafarnib | Small Molecule | Protein farnesyltransferase inhibitor | 1 | 1 | 18 | C1829 · CHEMBL298734 |
| Raltitrexed | Small Molecule | Thymidylate synthase inhibitor | 1 | 1 | 33 | C1804 · CHEMBL225071 |
| Telmisartan | Small Molecule | Type-1 angiotensin II receptor antagonist | 1 | 1 | 5 | C47746 · CHEMBL1017 |
| Allogeneic T cells genetically modified with a retroviral vector encoding for a truncated form of the human low affinity nerve growth factor receptor (ΔLNGFR) and the herpes simplex I virus thymidine kinase (HSV-TK Mut2) | — | Somatic cell supplemental therapy | 1 | 0 | 0 | CHEMBL5315097 |
| Altretamine | Small Molecule | DNA inhibitor | 1 | 0 | 1 | CHEMBL1455 |
| Amsacrine | Small Molecule | DNA topoisomerase II inhibitor | 1 | 0 | 8 | CHEMBL43 |
| Autologous peripheral-blood mononuclear cells activated with prostatic acid phosphatase granulocyte-macrophage colony-stimulating factor | — | — | 1 | 0 | 34 | — |
| Bacillus Calmette-Guerin BCG | — | — | 1 | 0 | 9 | — |
| Bacillus Calmette-Guérin (bcg) - Strain Russian Bcg-I | — | — | 1 | 0 | 0 | — |
| Bacillus Calmette-Guerin (bcg) Strain Tice | — | — | 1 | 0 | 0 | — |
| Bacillus Calmette-Guerin (bcg) Substrain Connaught | — | — | 1 | 0 | 0 | — |
| Bacillus Calmette-Guerin (bcg) Substrain Montreal | — | — | 1 | 0 | 0 | — |
| Dinutuximab Beta | Monoclonal Antibody | Disialoganglioside GD2 inhibitor | 1 | 0 | 7 | CHEMBL5315068 |
| Histamine | Small Molecule | Histamine H1 receptor agonist; Topical analgesic; Immunoprotectant | 1 | 0 | 4 | CHEMBL90 |
| Interferon Alfacon-1 | Other | Interferon alpha/beta receptor agonist | 1 | 0 | 2 | CHEMBL1201557 |