Drug · Small Molecule

Dacarbazine

CI-DRUG-00000174Explore in graph →NCIt C411 CHEMBL476 CIViC Approved

Regulatory

Approvals (6)

Each record names the authority, jurisdiction, indication text and status. A drug approved in one jurisdiction for one indication is not 'approved' in general.

health-canada-dpdRegulatory6 approval records from 2 sources (hover a row badge for its dataset) · authority, jurisdiction and indication text as published.

Jurisdiction · authority	Cancer	Indication	Status	Approval date	Source
CA Health Canada	—	Marketed in Canada as DACARBAZINE FOR INJECTION BP (DIN 02241445) under ATC L01AX04 DACARBAZINE. Indications are not published in the Drug Product Database — see the Health Canada Product Monograph.	approvedsource: Marketed	Apr 4, 2000	health-canada-dpd
CA Health Canada	—	Marketed in Canada as DTIC-DOME -PWS IV 200MG/VIAL (DIN 02154854) under ATC L01AX04 DACARBAZINE. Indications are not published in the Drug Product Database — see the Health Canada Product Monograph.	withdrawnsource: Cancelled Post Marketsince May 31, 2005	Oct 10, 1996	health-canada-dpd
CA Health Canada	—	Marketed in Canada as DTIC DOME INJ 200MG/VIAL (DIN 00521183) under ATC L01AX04 DACARBAZINE. Indications are not published in the Drug Product Database — see the Health Canada Product Monograph.	withdrawnsource: Cancelled Post Market

Health Canada records are DIN-level: one row per marketed product (brand, strength, form). The Drug Product Database does not publish indications, so no cancer is stated for these rows, and a cancelled or dormant DIN is the status of that one product — not a withdrawal of the molecule.

Data updated yesterdaySource updated unknown

Derived

Development pipeline

Most advanced stage across all cancers, then per top-level cancer reached through trial conditions or approval indications. Approval in any ingested jurisdiction outranks trial phase; counts are interventional studies.

Scope	Stage	Max phase	Active	Recruiting	Phase 3	Trials	Approvals	Jurisdictions	First approval	First trial
All cancers	Approved	Phase 4	32	16	52	156	6	CA, US	Aug 27, 1998	1990-07
Hodgkin Lymphoma	Phase4	Phase 4	23	10	10	48	0	—	—	Jan 25, 1994
Cutaneous Melanoma	Phase2	Phase 2	0	0	0	1	0	—	—	2014-01
Malignant Thyroid Gland Neoplasm	Phase2	Phase 2	0	0	0	1	0	—

Curated evidence

Clinical evidence (1)

CIViC items in which this therapy appears, grouped by cancer context, then molecular profile. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FN1 EDB1
Dacarbazine + L19IL2Combination

Clinical trials

Trials with this intervention (156)

Most recently updated first, 50 per page.

clinicaltrialsPublishedShowing 101–150 of 156 studies · status and phase as posted by the registrant; each row links to the study record.

NCT	Title	Status	Phase	Enrollment (n)	Sponsor	Countries	Last update	Source
NCT01705392	Bevacizumab vs Dacarbazine in Metastatic Melanoma	terminated	Phase 2	2	Haukeland University HospitalOTHER	1	Feb 24, 2017	clinicaltrials
NCT00802880	Dacarbazine for Metastatic Soft Tissue and Bone Sarcoma	completed	Phase 2	80	Washington University School of Medicine

Molecule

Record

Kind: Small Molecule
Mechanism: DNA inhibitor
UNII: 7GR28W0FJI
Aliases: 1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide, Asercit, Biocarbazine, Biocarbazine r, Dacarbasine, Dacarbazina, Dacarbazina Almirall, Dacarbazine, Dacarbazine - DTIC, Dacarbazinum, Dacatic, Dakarbazin, Decarbazine, Deticene, Detimedac, DIC, Dicarbazine, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl (triazeno) Imidazolecarboxamide, Dimethyl Triazeno Imidazole Carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, Dtic-dome, DTIC-Dome, DTIC-DOME -PWS, Fauldetic … (+5)

Data updated 15 hours agoSource updated unknown

Identifiers

Codes (11)

Upstream identifiers kept as first-class codes; each links to its registry where a stable public URL exists.

System	Code	Label
ATC (WHO)	L01AX04	DACARBAZINE
DIN (Health Canada)	00521183