Vascular Neoplasm

In this 2019 study, targeted RNA sequencing using the Archer FusionPlex technology was validated and implemented to detect oncogenic fusion transcripts in 62 genes recurrently rearranged in solid tumo… (full text at CIViC)

PMID 30459475 · Zhu et al., 2019 · Open in CIViC

One patient with angiosarcoma was initially treated with sorafenib, an inhibitor of VEGFR2, and developed progressive disease. The patient then received pazopanib, an inhibitor of VEGFR2 and VEGFR3 an… (full text at CIViC)

PMID 27160228 · Ravi et al., 2016 · Open in CIViC

In this study, the authors investigated a case of pseudomyogenic hemangioendothelioma in a 33-year-old woman presenting with multifocal lytic bone lesions. Previous studies had demonstrated recurrent … (full text at CIViC)

PMID 31243110 · Panagopoulos et al., 2019 · Open in CIViC

FOS was found fused with 3 different genes in 3 cases of bone epithelioid hemangioma. The fusion partners were not recurrent, respectively MBNL1, VIM and a lincRNA. The truncation of the FOS gene wou… (full text at CIViC)

PMID 26173738 · van IJzendoorn et al., 2015 · Open in CIViC

An infant was diagnosed prenatally at 20 weeks gestation with segmented vascular tumors involving her liver, umbilicus, and skin of the upper back and torso. She developed congestive heart failure imm… (full text at CIViC)

PMID 32255239 · Smith et al., 2020 · Open in CIViC

A 33-week gestational age male infant was prematurely delivered due to ultrasound findings of a large mass on his upper trunk. Segmentally distributed purple plaques were revealed on his right chest a… (full text at CIViC)

PMID 32255239 · Smith et al., 2020 · Open in CIViC

COS-7 cells were transiently transfected with expression constructs encoding cDNAs for wild-type or A1065T-mutant KDR. Autophosphorylation was observed on tyrosine of mutant cells, but not wild-type c… (full text at CIViC)

PMID 19723655 · Antonescu et al., 2009 · Open in CIViC

The angiosarcoma harbored amplifications of VEGFR2 (KDR) of 8 copies and VEGFR3 (FLT4) of 16 copies. The patient was initially treated with sorafenib, an inhibitor of VEGFR2, and developed progressive… (full text at CIViC)

PMID 27160228 · Ravi et al., 2016 · Open in CIViC

COS-7 cells were transiently transfected with expression constructs encoding cDNAs for wild-type or D717V-mutant KDR. Autophosphorylation was observed on tyrosine of mutant cells, but not wild-type ce… (full text at CIViC)

PMID 19723655 · Antonescu et al., 2009 · Open in CIViC

gene expression assay performed earlier demonstrated a This case report of a patient with refractory breast angiosarcoma shows a potential therapeutic benefit of sunitinib due to the upregulation of V… (full text at CIViC)

PMID 25639617 · Silva et al., 2015 · Open in CIViC

A cohort of angiosarcomas (n=36) was sequenced and revealed to contain recurrent mutations in PTPRB (10/36) which were predominantly truncating or splice variants which impact the tyrosine phosphotase… (full text at CIViC)

PMID 24633157 · Behjati et al., 2014 · Open in CIViC

The endothelial phosphatase PTPRB, a negative regulator of vascular growth factor tyrosine kinases, harbored truncating mutations in 10 of 39 angiosarcomas (26%) which correlated with MYC amplificatio… (full text at CIViC)

PMID 24633157 · Behjati et al., 2014 · Open in CIViC

In this study, the authors analyzed two index cases of pseudomyogenic haemangioendothelioma and 10 additional cases by interphase FISH. Both index cases showed a balanced t(7;19)(q22;q13) translocatio… (full text at CIViC)

PMID 24374978 · Walther et al., 2014 · Open in CIViC