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CancerIndex

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Thoracic Neoplasm — Research · CancerIndex

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Neoplasm
Neoplasm by Site
Thoracic Neoplasm

Cancer Family

Thoracic Neoplasm

CI-CAN-00000054Explore in graph →

Non-malignant2,891 active trials51 approved drugs626 evidence items

NCIt: C3406
MeSH: D013899

Overview
Statistics
Survival
Genomics51
Variants & evidence626
Drugs128
Trials12160
Research
Rankings
Sources & provenance

Research activity

PubMed record counts

Each count is the number of PubMed records returned by the exact query shown, at the time it was run. Counts are research-activity signals, not quality measures.

Data not yet available

No PubMed query has been run for this entity. Counts require a MeSH-anchored query built from the entity's terminology mappings; the query string is stored with each count so it can be reproduced.

What CancerIndex knows

Trials tab
Methodology: publication counts

Literature

Linked publications (479)

Publications linked to this entity or its descendants, newest first, 25 per page. Link method and validation status are shown; 'candidate' links have not been reviewed.

pubmedProvenance

Source: PubMed (NLM)
Dataset: PubMed E-utilities
Retrieved: Sep 8, 2026
Layer: normalized (units and labels harmonized; values unchanged)

PublishedShowing 351–375 of 479 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Presence of MET exon 14 skipping and fusion as mechanism of osimertinb resistance in a lung adenocarcinoma with an EGFR exon 19 deletion that responds to combination of capmatinib and osimertinb: A case report.
· Heliyon · 2023 · PMID 38074875 · validated civic_curation pubmed
Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer.
· J Thorac Oncol · 2013 · PMID 23524406 · validated civic_curation pubmed
A patient with lung adenocarcinoma and RET fusion treated with vandetanib.
· J Thorac Oncol · 2013 · PMID 23584301 · validated civic_curation pubmed
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine.
· Nat Med · 2014 · PMID 24836576 · validated civic_curation pubmed
Response to Crizotinib Observed in Lung Adenocarcinoma with MET Copy Number Gain but without a High-Level MET/CEP7 Ratio, MET Overexpression, or Exon 14 Splicing Mutations.
· J Thorac Oncol · 2016 · PMID 26724472 · validated civic_curation pubmed
Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement.
· Lung Cancer · 2014 · PMID 24192513 · validated civic_curation pubmed
A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALK fusion gene.

Showing 351–375 of 479 publications

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· BMC Cancer · 2012 · PMID 23181703 · validated civic_curation pubmed

Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer.

· J Clin Oncol · 2010 · PMID 20940188 · validated civic_curation pubmed

Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I).

· Jpn J Clin Oncol · 2010 · PMID 20522446 · validated civic_curation pubmed

RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors.

· Cancer Discov · 2015 · PMID 26370156 · validated civic_curation pubmed

Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib.

· J Thorac Oncol · 2014 · PMID 25393796 · validated civic_curation pubmed

Genome sequencing for nonsmall-cell lung cancer identifies a basis for nintedanib sensitivity.

· Ann Oncol · 2016 · PMID 26787234 · validated civic_curation pubmed

Systemic and CNS activity of the RET inhibitor vandetanib combined with the mTOR inhibitor everolimus in KIF5B-RET re-arranged non-small cell lung cancer with brain metastases.

· Lung Cancer · 2015 · PMID 25982012 · validated civic_curation pubmed

Lazarus-Type Response to Crizotinib in a Patient with Poor Performance Status and Advanced MET Exon 14 Skipping Mutation-Positive Lung Adenocarcinoma.

· J Thorac Oncol · 2016 · PMID 26845194 · validated civic_curation pubmed

Acquired Resistance to Crizotinib in NSCLC with MET Exon 14 Skipping.

· J Thorac Oncol · 2016 · PMID 27343442 · validated civic_curation pubmed

Responses to Crizotinib Can Occur in High-Level MET-Amplified Non-Small Cell Lung Cancer Independent of MET Exon 14 Alterations.

· J Thorac Oncol · 2017 · PMID 27664533 · validated civic_curation pubmed

EGFR-independent mechanisms of acquired resistance to AZD9291 in EGFR T790M-positive NSCLC patients.

· Ann Oncol · 2015 · PMID 26269204 · validated civic_curation pubmed

S768I Mutation in EGFR in Patients with Lung Cancer.

· J Thorac Oncol · 2016 · PMID 27211795 · validated civic_curation pubmed

Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing.

· PLoS One · 2016 · PMID 27045755 · validated civic_curation pubmed

Routine EGFR molecular analysis in non-small-cell lung cancer patients is feasible: exons 18-21 sequencing results of 753 patients and subsequent clinical outcomes.

· Lung · 2013 · PMID 23749122 · validated civic_curation pubmed

Effectiveness of EGFR-TKIs in a Patient with Lung Adenocarcinoma Harboring an EGFR-RAD51 Fusion.

· Oncologist · 2019 · PMID 31064887 · validated civic_curation pubmed

A never-smoker lung adenocarcinoma patient with a MET exon 14 mutation (D1028N) and a rapid partial response after crizotinib.

· Invest New Drugs · 2016 · PMID 26892698 · validated civic_curation pubmed

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.

· Cancer Discov · 2014 · PMID 24302556 · validated civic_curation pubmed

Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations.

· Mol Cancer Ther · 2021 · PMID 34625502 · validated civic_curation pubmed

Emerging a Novel VOPP1-EGFR Fusion Coexistent With T790M as an Acquired Resistance Mechanism to Prior Icotinib and Sensitive to Osimertinib in a Patient With EGFR L858R Lung Adenocarcinoma: A Case Report.

· Front Oncol · 2021 · PMID 35004270 · validated civic_curation pubmed