Soft Tissue Sarcoma — Variants & evidence

Soft Tissue Sarcoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

54 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 51–54 of 54 evidence items (4 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ALK Fusion1
Crizotinib	Vaginal SarcomaALIAS	Predictive	C	Supports Sensitivity Response	2	accepted	EID6042 Patient was 34-year-old woman with vaginal sarcoma, which was excised with positive surgical margins. Fluorescence in situ hybridization testing of her tumor revealed anaplastic lymphoma kinase gene … (full text at CIViC) PMID 26942346 · Forde et al., 2016 · Open in CIViC	civic
NUTM2A Fusion + NUTM2B Fusion + NUTM2E FusionNUTM2A NUTM2B NUTM2E3
(diagnostic)	Clear Cell Sarcoma of the KidneyALIAS	Diagnostic	B	Supports Positive	3	accepted	EID11782 In this 2012 study O’Meara et al. included 51 clear cell sarcoma of kidney (CCSK). Using an index CCSK with the t(10;17)(q22;p13) identified by cytogenetics, they were able to map the breakpoints and … (full text at CIViC) PMID 22294382 · O'Meara et al., 2012 · Open in CIViC	civic
〃	Clear Cell Sarcoma of the KidneyALIAS	Diagnostic	C	Supports Positive	2	accepted	EID11783 In this 2020 study Kenny et al. included 68 cases of clear cell sarcoma of the kidney (CCSK). Using RT-PCR with RNA extracted from FFPE tumour tissue they detected a YWHAE::NUTM2 fusion transcript in… (full text at CIViC) PMID 32364435 · Kenny et al., 2020 · Open in CIViC

Data updated 12 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.