Sarcoma — Variants & evidence

Sarcoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

256 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 251–256 of 256 evidence items (6 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TFCP2 Fusion2
(diagnostic)	Spindle Cell Rhabdomyosarcoma	Diagnostic	B	Supports Positive	3	accepted	EID12335 In this study, the authors investigated the diagnostic role of TFCP2 fusions in spindle cell/sclerosing rhabdomyosarcoma (SC/S-RMS), a rare and aggressive subtype of rhabdomyosarcoma. While SC/S-RMS e… (full text at CIViC) PMID 31383960 · Le Loarer et al., 2020 · Open in CIViC	civic
〃	Spindle Cell Rhabdomyosarcoma	Diagnostic	C	Supports Positive	4	accepted	EID12325 This study investigated the role of TFCP2-related gene fusions in primary intraosseous rhabdomyosarcomas (PIOS), particularly within spindle cell and sclerosing rhabdomyosarcoma subtypes. The analysis… (full text at CIViC) PMID 30720533 · Agaram et al., 2019 · Open in CIViC	civic
NUTM2A Fusion + NUTM2B Fusion + NUTM2E FusionNUTM2A NUTM2B NUTM2E3
(diagnostic)	Clear Cell Sarcoma of the KidneyALIAS	Diagnostic	B	Supports Positive	3	accepted	EID11782 In this 2012 study O’Meara et al. included 51 clear cell sarcoma of kidney (CCSK). Using an index CCSK with the t(10;17)(q22;p13) identified by cytogenetics, they were able to map the breakpoints and … (full text at CIViC) PMID 22294382 · O'Meara et al., 2012 · Open in CIViC	civic
〃	Clear Cell Sarcoma of the KidneyALIAS	Diagnostic	C	Supports Positive	2	accepted	EID11783 In this 2020 study Kenny et al. included 68 cases of clear cell sarcoma of the kidney (CCSK). Using RT-PCR with RNA extracted from FFPE tumour tissue they detected a YWHAE::NUTM2 fusion transcript in… (full text at CIViC) PMID 32364435 · Kenny et al., 2020 · Open in CIViC
ZNF217 Overexpression1
Triciribine	Osteosarcoma	Predictive	D	Supports Sensitivity Response	2	submitted	EID12210 In an orthotopic mouse model of osteosarcoma (OSA), triciribine (TCN) treatment significantly reduces tumour growth and weight in both SJSA-1 and HOS cell line injections, with 5.4- and 3.0-fold reduc… (full text at CIViC) PMID 32999043 · Smeester et al., 2020 · Open in CIViC	civic

Data updated 9 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.