PEComa — Variants & evidence

PEComa — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TFE3 Fusion3
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID11606 In this study, the authors evaluated 60 Xp11 translocation neoplasms, including 8 perivascular epithelioid cell tumors (PEComas), to characterize the diagnostic significance of TFE3 fusion variants. U… (full text at CIViC) PMID 26975036 · Argani et al., 2016 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID12690 In this study the authors examined six gynecologic tract perivascular epithelioid cell tumors (PEComas) that were previously diagnosed as PEComa but demonstrated unusual morphology suggestive of TFE3 … (full text at CIViC) PMID 25517951 · Schoolmeester et al., 2015 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID12691 In this 2025 study, the authors included 14 confirmed TFE3-rearranged perivascular epithelioid cell tumors (PEComas), previously classified as benign (9 tumors) or malignant (5 tumors), and compared t… (full text at CIViC) PMID 40462401 · Papke et al., 2025 · Open in CIViC	civic

Data updated 2 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.