Precursor Condition
Monoclonal Gammopathy of Undetermined Significance
CI-CAN-00006048MGUSExplore in graph →
HematologicPrecursor13 active trials
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Precursor Condition
CI-CAN-00006048MGUSExplore in graph →
Clinical trials
59 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT04920084 | A Study of a Plant-Based Diet in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) | active not recruiting | N/A | 23 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Sep 21, 2026 | clinicaltrials |
| NCT05283993 | A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH | recruiting | — | 2,000 | Peking University First HospitalOTHER | 1 | Sep 16, 2026 | clinicaltrials |
| NCT01139476 | Specimen Collection for Agricultural Health Study Cohort Pesticide Exposure Study | completed | — | 1,892 | National Cancer Institute (NCI)NIH | 1 | Aug 28, 2026 | clinicaltrials |
| NCT05831358 | Early Detection of Multiple Myeloma to Fight Cancer Disparities: A Screening and Patient Navigation Program | active not recruiting | N/A | 201 | Case Comprehensive Cancer CenterOTHER | 1 | Aug 18, 2026 | clinicaltrials |
| NCT06472830 | MGUS/MM Awareness and Genetics Insights Campaign (MAGIC) Screening Study(MAGIC) | enrolling by invitation | — | 1,000 | Mayo ClinicOTHER | 1 | Aug 11, 2026 | clinicaltrials |
| NCT06644625 | CHAAMP (CHArlotte Advocate MGUS Project) Internal Pilot Study | recruiting | — | 1,665 | Wake Forest University Health SciencesOTHER | 1 | Jul 13, 2026 | clinicaltrials |
| NCT06140524 | A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma(LINKER-MGUS1) | recruiting | Phase 2 | 116 | Regeneron PharmaceuticalsINDUSTRY | 7 | Jul 8, 2026 | clinicaltrials |
| NCT06083922 | A Study of CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) Plus Daratumumab in People With Monoclonal Gammopathy of Renal Significance (MGRS) | recruiting | Phase 2 | 20 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Jul 6, 2026 | clinicaltrials |
| NCT07684274 | Early Screening for Multiple Myeloma Based on Liquid Biopsy cfDNA Fragmentomics | not yet recruiting | — | 290 | The First Affiliated Hospital with Nanjing Medical UniversityOTHER | 0 | Jul 6, 2026 | clinicaltrials |
| NCT06559033 | Determine the Frequency of Variants in the GBA/PSAP Genes in Patients With MM or MGUS(GAMY) | recruiting | — | 300 | University Hospital, RouenOTHER | 1 | Jun 10, 2026 | clinicaltrials |
| NCT07624760 | Early Detection of Amyloidosis in Monoclonal Gammopathy Using Nuclear Medicine Imaging(MGUS-PET) | not yet recruiting | N/A | 50 | University of ZurichOTHER | 1 | Jun 3, 2026 | clinicaltrials |
| NCT04731844 | Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer | completed | Phase 2 | 30 | University of RochesterOTHER | 1 | May 12, 2026 | clinicaltrials |
| NCT02269592 | Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome | recruiting | — | 10,000 | Dana-Farber Cancer InstituteOTHER | 1 | May 7, 2026 | clinicaltrials |
| NCT07446777 | FAST-M: Prolonged Overnight Fasting and Mediterranean Dietary Intervention for Patients With Multiple Myeloma or Its Precursor Disease(FAST-M) | recruiting | N/A | 120 | University of MiamiOTHER | 1 | May 1, 2026 | clinicaltrials |
| NCT07214324 | Integrative Multi-omics Analysis to Predict Monoclonal Gammopathies Clinical Evolution(PNRR-2022-1237) | recruiting | — | 60 | Azienda USL Reggio Emilia - IRCCSOTHER_GOV | 1 | Apr 23, 2026 | clinicaltrials |
| NCT02726750 | Observational Prospective Research Study In Monoclonal Gammopathies leadINg to Myeloma | recruiting | — | 200 | M.D. Anderson Cancer CenterOTHER | 1 | Apr 21, 2026 | clinicaltrials |
| NCT05640843 | A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) | recruiting | N/A | 180 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Apr 16, 2026 | clinicaltrials |
| NCT06383143 | Promoting Diagnosis and Management of AL in Italy (ProDigALIty)(ProDigALIty) | recruiting | — | 760 | Fondazione IRCCS Policlinico San Matteo di PaviaOTHER | 1 | Apr 16, 2026 | clinicaltrials |
| NCT05136807 | Quality of Life in Patients With Asymptomatic Monoclonal Gammopathies | recruiting | — | 400 | M.D. Anderson Cancer CenterOTHER | 1 | Apr 15, 2026 | clinicaltrials |
| NCT05361694 | Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Multiple Myeloma (MM) Precursor Conditions(TRANSFORMM) | recruiting | — | 1,000 | University of MiamiOTHER | 1 | Apr 9, 2026 | clinicaltrials |
| NCT01408225 | Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource(B-SCR-MM) | recruiting | — | 5,000 | Ohio State University Comprehensive Cancer CenterOTHER | 1 | Mar 23, 2026 | clinicaltrials |
| NCT05969821 | Clonal Hematopoiesis of Immunological Significance(CHIS) | not yet recruiting | — | 5,000 | Assistance Publique - Hôpitaux de ParisOTHER | 1 | Mar 23, 2026 | clinicaltrials |
| NCT07448779 | Investigating the Pathogenic Role of N-glycosylation in AL Amyloidosis: Molecular Bases, Diagnosis, and Treatment(GlycAL) | recruiting | — | 100 | Fondazione IRCCS Policlinico San Matteo di PaviaOTHER | 1 | Mar 4, 2026 | clinicaltrials |
| NCT04850846 | Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma | active not recruiting | Phase 2 | 60 | Dana-Farber Cancer InstituteOTHER | 1 | Feb 9, 2026 | clinicaltrials |
| NCT01237054 | Imaging in MGUS, SMM and MM | completed | Phase 2 | 31 | National Cancer Institute (NCI)NIH | 1 | Feb 6, 2026 | clinicaltrials |
| NCT07305662 | Exploring the Effects of Korean-Style Mediterranean Diet (KORMED) and Physical Activity Measurement in Patients With MGUS/SMM: A Pilot Study(KORMED-PA Stud) | not yet recruiting | N/A | 20 | Seoul National University Bundang HospitalOTHER | 1 | Jan 21, 2026 | clinicaltrials |
| NCT05065554 | ACALA-R In Predominantly Demyelinating IgM Mediated Neuropathy | active not recruiting | Phase 2 | 12 | Shayna Sarosiek, MDOTHER | 1 | Dec 5, 2025 | clinicaltrials |
| NCT06237803 | European Myeloma Network (EMN) Sample Project(EMN36) | recruiting | — | 6,000 | European Myeloma Network B.V.NETWORK | 10 | Dec 3, 2025 | clinicaltrials |
| NCT06055894 | A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM) or Monoclonal Gammopathy of Undetermined Significance (MGUS) | recruiting | N/A | 200 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Nov 13, 2025 | clinicaltrials |
| NCT04114084 | Sleep Apnea in Patients With MGUS and MM | recruiting | — | 200 | Michael TomassonOTHER | 1 | Nov 10, 2025 | clinicaltrials |
| NCT03327597 | Iceland Screens, Treats or Prevents Multiple Myeloma(iStopMM) | active not recruiting | N/A | 80,761 | University of IcelandOTHER | 1 | Sep 30, 2025 | clinicaltrials |
| NCT05565638 | PROFAST Intervention in Precursor Multiple Myeloma(PROFAST) | completed | N/A | 23 | Dana-Farber Cancer InstituteOTHER | 1 | Sep 25, 2025 | clinicaltrials |
| NCT03951220 | The Development and Pilot Testing of a New MR Imaging Protocol to Quantify Myeloma Disease Burden and Bone Loss(LOOMIS) | completed | — | 67 | Oxford University Hospitals NHS TrustOTHER | 1 | Aug 19, 2025 | clinicaltrials |
| NCT06895291 | Whole Body MRI in Oncology(ONCO-MRI) | recruiting | — | 1,000 | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCSOTHER | 1 | Mar 30, 2025 | clinicaltrials |
| NCT06690593 | Characteristics and Clinical Significance of Gut Microbiota in Patients With Monoclonal Gammopathy | recruiting | — | 2,990 | Zhujiang HospitalOTHER | 1 | Dec 27, 2024 | clinicaltrials |
| NCT04615572 | Screening to Improve Survival in AL Amyloidosis | completed | — | 35 | Tufts Medical CenterOTHER | 1 | Oct 28, 2024 | clinicaltrials |
| NCT02298816 | B-Cell Hematologic Malignancy Vaccination Registry(HMvax-Regist) | withdrawn | — | 0 | Wake Forest University Health SciencesOTHER | 1 | Oct 3, 2024 | clinicaltrials |
| NCT06418477 | Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone Therapy for Patients with MIDD | recruiting | Phase 2 | 20 | Peking University People's HospitalOTHER | 1 | Oct 1, 2024 | clinicaltrials |
| NCT06539832 | Intestinal Flora and Immunity in Monoclonal Gammopathy Patients | recruiting | — | 300 | Zhujiang HospitalOTHER | 1 | Sep 19, 2024 | clinicaltrials |
| NCT03119883 | Dysregulation of Glutamine Activity in the Pathogenesis of Multiple Myeloma | completed | N/A | 35 | Mayo ClinicOTHER | 1 | Aug 9, 2024 | clinicaltrials |
| NCT01588015 | Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant | completed | Phase 1 | 36 | City of Hope Medical CenterOTHER | 1 | Apr 2, 2024 | clinicaltrials |
| NCT04439006 | Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization | completed | Phase 1 | 10 | Jennifer WoyachOTHER | 1 | Dec 26, 2023 | clinicaltrials |
| NCT05965115 | The China M-protein Screening Project in First-degree Relatives of Myeloma Patient - The CHAPERONE Study(CHAPERONE) | recruiting | — | 10,000 | Shanghai Zhongshan HospitalOTHER | 1 | Aug 1, 2023 | clinicaltrials |
| NCT05114109 | Isatuximab in Type I Cryoglobulinemia(ICE) | unknown | Phase 2 | 21 | Assistance Publique - Hôpitaux de ParisOTHER | 0 | Nov 9, 2021 | clinicaltrials |
| NCT05047107 | Biology and Genetics of Smouldering Myeloma(COSMOS) | unknown | — | 500 | University College, LondonOTHER | 1 | Sep 16, 2021 | clinicaltrials |
| NCT04727294 | MGUS, SMM, and MM Patient Experience With Coronavirus 19 (COVID-19) Survey | unknown | — | 1,500 | HealthTree FoundationOTHER | 1 | Aug 4, 2021 | clinicaltrials |
| NCT01079429 | Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM.(GENOMGUS) | terminated | — | 1,200 | Rennes University HospitalOTHER | 1 | Apr 15, 2021 | clinicaltrials |
| NCT01109407 | Natural History Study of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Myeloma (SMM) | terminated | — | 225 | National Cancer Institute (NCI)NIH | 1 | Mar 8, 2021 | clinicaltrials |
| NCT04702932 | Establishment of Genomic, Transcriptomic and Functional Characteristics of Tumor Cells in Hyperinflammatory Hemopathies(GEN-HEMO-INF) | not yet recruiting | — | 30 | Assistance Publique - Hôpitaux de ParisOTHER | 1 | Jan 11, 2021 | clinicaltrials |
| NCT01571726 | Imaging Studies and the Development of Multiple Myeloma | withdrawn | Phase 2 | 0 | National Cancer Institute (NCI)NIH | 0 | Dec 16, 2019 | clinicaltrials |
Data updated 5 days agoSource updated Sep 21, 2026source: clinicaltrials