Specimen Collection for Agricultural Health Study Cohort Pesticide Exposure Study

Background: \- Multiple myeloma (MM), a type of cancer that affects the white blood cells, is often preceded by a precancerous disorder known as monoclonal gammopathy of undetermined significance (MGUS). Farmers and other agricultural workers have a higher risk of developing MGUS and MM, possibly because of their exposure to certain pesticides. Researchers are interested in studying biological specimens taken from participants in the Agricultural Health Study - specifically, pesticide applicators at least 50 years of age who do not have cancer- to better understand the development of MGUS and MM. Objectives: * To collect biological specimens from Agricultural Health Study participants for further research. * To examine the relationship between pesticide exposure and MGUS/MM. Eligibility: \- Male pesticide applicators who are over 50 years of age, cancer-free, and participating in the Agricultural Health Study. Design: * Two groups of participants will complete the study: a general group and a smaller group of individuals who have been exposed to the pesticide diazinon. * All participants will receive an initial contact letter with information about the study, followed by a phone call to administer a screening questionnaire and arrange a home visit from a researcher within the next month. * Participants will receive by mail a urine specimen kit that will be collected at the home visit. * During the home visit, a study researcher will take blood samples and collect the urine sample, and will administer another questionnaire. * Participants in the group exposed to diazinon will have three home visits for the study: (1) prior to pesticide exposure, (2) the day after participants stop using diazinon, and (3) about 21 days after the second visit. The first visit will take place in the off-season from January to March; the second and third visits will be conducted between April and August. * No treatment will be provided as part of this study.

Sex

Male

Minimum age

18 Years

Maximum age

100 Years

* INCLUSION CRITERIA:

Selected participants in the Agricultural Health Study are invited to participate in this aspect of the study.

1. Male private pesticide applicator;
2. Alive as of the latest update of the National Death Index G\\fDD and over 50 years of age at the time of initial contact:
3. Cancer free as of the most recent linkage with the appropriateCancer Registry;
4. Completed phase I, II and III interviews (these study subjects have the most comprehensive exposure evaluation and also will be the most interested in the study).

EXCLUSION CRITERIA:

1. Deceased or no longer residing in Iowa or North Carolina;
2. Ever diagnosed with any type of cancer other than non-melanoma skin cancer;
3. Unable to speak English;
4. Have a blood clotting disorder such as hemophilia; or
5. Registered with the AHS as a "no contact".