Malignant Liver Neoplasm — Variants & evidence

Malignant Liver Neoplasm — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

54 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 51–54 of 54 evidence items (4 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PROM1 EXPRESSION1
Sorafenib	Hepatocellular Carcinoma	Predictive	B	Supports Resistance	2	accepted	EID926 CD133 (PROM1) expression in 39 samples of hepatocellular carcinomas was correlated with JNK activity. Both were more highly expressed in patients not responding to sorafenib. CD133+ cells (sorted) wer… (full text at CIViC) PMID 22596232 · Hagiwara et al., 2012 · Open in CIViC	civic
PTPN6 Underexpression1
(prognostic)	Hepatocellular Carcinoma	Prognostic	D	Supports Poor Outcome	4	submitted	EID6390 SHP-1 has been shown to be a tumor suppressor in hematopoietic cancers. Reduced SHP-1 expression in HCC correlates to aggressive tumor behavior resulting in a poor prognosis for patients. PMID 29776962 · Wen et al., 2018 · Open in CIViC	civic
RAF1 Amplification1
Sorafenib	Hepatocellular Carcinoma	Predictive	D	Supports Sensitivity Response	2	submitted	EID9113 Through the histological examination of 25 patient tumor samples with hepatocellular carcinoma, the efficacy of postoperative sorafenib treatment may be correlated with higher levels of c-Raf-1 expres… (full text at CIViC) PMID 26981887 · Lei et al., 2016 · Open in CIViC	civic
VEGFC Overexpression1
Sunitinib	Hepatocellular Carcinoma	Predictive	B	Supports Sensitivity Response	4	submitted	EID7987 Phase 2 trial of adult hepatocellular patients treated with sunitinib analyzed how baseline concentration of different soluble VEGF proteins predict overall survival (OS) and time to progression (TTP)… (full text at CIViC) PMID 21787417 · Harmon et al., 2011 · Open in CIViC	civic

Data updated 9 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.