Subtype
Malignant Large Intestinal Neoplasm
CI-CAN-00003173Explore in graph →
1,622 active trials21 approved drugs383 evidence items
- NCIt
- C215202
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Subtype
CI-CAN-00003173Explore in graph →
Clinical trials
7,500 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (742)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT07651007 | Short-course RT Followed by NALIRIFOX Plus Pucotenlimab as Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer With MSS/pMMR | not yet recruiting | Phase 2 | 29 | Wang XinOTHER | 0 | Jun 16, 2026 | clinicaltrials |
| NCT07648589 | Glucose Homeostasis and Shared Genetic Factors in Colorectal Cancer(BRIDGE-CRCDM) | not yet recruiting | — | 200 | Chang Gung Memorial HospitalOTHER | 0 | Jun 15, 2026 |
| clinicaltrials |
| NCT07612007 | HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization | not yet recruiting | Phase 2 | 80 | Mayo ClinicOTHER | 1 | Jun 12, 2026 | clinicaltrials |
| NCT07638956 | ICG in Colon Cancer(ICG) | not yet recruiting | N/A | 25 | Tanta UniversityOTHER | 0 | Jun 12, 2026 | clinicaltrials |
| NCT07645118 | Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer(IMPERIA) | not yet recruiting | Phase 2 | 10 | Dr. Te VuongOTHER | 1 | Jun 12, 2026 | clinicaltrials |
| NCT07318389 | ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer | not yet recruiting | Early Phase 1 | 100 | M.D. Anderson Cancer CenterOTHER | 1 | Jun 11, 2026 | clinicaltrials |
| NCT06446557 | De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer(DIAMOND) | not yet recruiting | Phase 3 | 408 | University Hospital, RouenOTHER | 1 | Jun 9, 2026 | clinicaltrials |
| NCT07306390 | Distribution and Analysis of Metastatic Lymph Nodes in Colorectal Cancer Patients (DIAMOND)(DIAMOND) | not yet recruiting | — | 1,200 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 1 | Jun 9, 2026 | clinicaltrials |
| NCT06882915 | Efficacy and Safety of Trifluridine/Tipiracil (TAS-102) Combined With Bevacizumab and Serplulimab in Patients With Metastatic Colorectal Cancer Undergoing Cytoreductive Surgery: A Single-Arm, Single-Center Clinical Study | not yet recruiting | Phase 1 | 20 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 0 | Jun 8, 2026 | clinicaltrials |
| NCT07632313 | Health Behavior Intervention for Colorectal Cancer Patients | not yet recruiting | N/A | 40 | Nanjing Medical UniversityOTHER | 1 | Jun 8, 2026 | clinicaltrials |
| NCT07611071 | AI-Integrated Emotional Granularity Training for Resilience and Quality of Life in Colorectal Cancer Survivors | not yet recruiting | N/A | 54 | The Hong Kong Polytechnic UniversityOTHER | 1 | Jun 4, 2026 | clinicaltrials |
| NCT07622550 | A Single-arm, Multicenter Clinical Study of Fruquintinib Combined With Serplulimab and Chemotherapy as First-line Treatment for Patients With RAS/BRAF-mutated Advanced Colorectal Cance | not yet recruiting | Phase 2 | 80 | Jiangsu Cancer Institute & HospitalOTHER | 1 | Jun 3, 2026 | clinicaltrials |
| NCT07624214 | Study of LT-010391 in Participants With KRAS G12D-Mutant Solid Tumors | not yet recruiting | Phase 1 | 198 | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd.INDUSTRY | 1 | Jun 3, 2026 | clinicaltrials |
| NCT07624916 | Transversus Abdominis Plane and Rectus Sheath Block for Robotic Colectomy | not yet recruiting | Phase 4 | 90 | Tri-Service General Hospital (TSGH)OTHER | 1 | Jun 3, 2026 | clinicaltrials |
| NCT07319104 | Liquid Biopsy in Early Colorectal Lesions(FECCO-BioBank) | not yet recruiting | — | 1,000 | University Hospital, MontpellierOTHER | 1 | Jun 2, 2026 | clinicaltrials |
| NCT07620743 | Noninvasive Early Diagnosis of Colorectal Cancer Using Odor-Targeted Capture, Point-of-Care Testing, and Intelligent Analysis | not yet recruiting | — | 453 | Beijing University of Chinese MedicineOTHER | 1 | Jun 2, 2026 | clinicaltrials |
| NCT07621497 | FOLFOX8 Versus mFOLFOX6 With Bevacizumab or Cetuximab for First-Line Unresectable Metastatic Colorectal Cancer (Phase II) | not yet recruiting | Phase 2 | 229 | Sun Yat-sen UniversityOTHER | 1 | Jun 2, 2026 | clinicaltrials |
| NCT07622017 | KORTUC (KRC-01) Plus Radiotherapy for Organ Preservation in Rectal Cancer(K-BOOST) | not yet recruiting | Phase 2 | 24 | Gustave Roussy, Cancer Campus, Grand ParisOTHER | 1 | Jun 2, 2026 | clinicaltrials |
| NCT06528353 | Blood Biomarkers Based Screening for HPV-driven OPC(SCREEN-HPV) | not yet recruiting | N/A | 10,000 | UNICANCEROTHER | 0 | May 26, 2026 | clinicaltrials |
| NCT07284394 | Liver-directed Chemotherapy After Surgery of Liver Metastases of Colorectal Cancer in Patients With High Risk of Recurrence of Their Disease(PACHA-02) | not yet recruiting | Phase 3 | 272 | UNICANCEROTHER | 0 | May 26, 2026 | clinicaltrials |
| NCT07605702 | The Canopy Cancer Collective Clinical Registry Protocol | not yet recruiting | — | 100,000 | Canopy Cancer Collective, LLCNETWORK | 1 | May 26, 2026 | clinicaltrials |
| NCT06890624 | mFOLFOXIRI Plus PD-1 Inhibitor vs mFOLFOX6 as Neoadjuvant Therapy for Locally Advanced Colon Cancer(OPTICAL-3) | not yet recruiting | Phase 2 | 138 | Sun Yat-sen UniversityOTHER | 0 | May 22, 2026 | clinicaltrials |
| NCT07599501 | Nutritional Supplementation to Improve Colorectal Cancer Surgery(NUTRICOLOR) | not yet recruiting | N/A | 190 | Istituto Clinico HumanitasOTHER | 1 | May 20, 2026 | clinicaltrials |
| NCT07359456 | Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases(COLIBRI-GI) | not yet recruiting | Phase 2 | 130 | UNICANCEROTHER | 1 | May 19, 2026 | clinicaltrials |
| NCT07595107 | Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal Cancer | not yet recruiting | — | 180 | Shandong Cancer Hospital and InstituteOTHER | 1 | May 19, 2026 | clinicaltrials |
| NCT07595276 | Comparing Efficacy and Safety of Enlituo® Versus Erbitux® Plus FOLFOX in Locally Advanced/Metastatic Colorectal Cancer With RAS/BRAF Wild-type and MSS/pMMR Status. | not yet recruiting | Phase 3 | 608 | Taizhou Mabtech Pharmaceutical Co.,LtdINDUSTRY | 1 | May 19, 2026 | clinicaltrials |
| NCT07596732 | Statewide Unified Network for Remote Intervention of Strength and Exercise(SUNRISE) | not yet recruiting | N/A | 120 | AdventHealth Translational Research InstituteOTHER | 0 | May 19, 2026 | clinicaltrials |
| NCT07014878 | A Study of DCTY1102 Injection in Participants With Advanced Solid Tumors | not yet recruiting | Phase 1 | 18 | Beijing DCTY Biotech Co.,Ltd.OTHER | 1 | May 18, 2026 | clinicaltrials |
| NCT07581626 | Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer | not yet recruiting | Phase 2 | 60 | Chinese PLA General HospitalOTHER | 1 | May 18, 2026 | clinicaltrials |
| NCT07590856 | A Preliminary Efficacy of SNA028 in Patients With Advanced Colorectal Cancer Positive for GPA33 | not yet recruiting | Early Phase 1 | 20 | SmartNuclide BiopharmaINDUSTRY | 1 | May 15, 2026 | clinicaltrials |
| NCT07586293 | Histidine and Immunotherapy Response in Colorectal Cancer | not yet recruiting | — | 150 | Jing-yuan Fang, MD, Ph. DOTHER | 0 | May 14, 2026 | clinicaltrials |
| NCT07587827 | Study Evaluating the Safety Feasibility and Efficacy of ODI-2001 Vaccine, a Personnalized Immunotherapy in Patients With Metastatic or Locally Advanced Colon Cancer or Pancreatic Cancer(ODI-2001-01) | not yet recruiting | Phase 1 | 77 | Centre Georges Francois LeclercOTHER | 1 | May 14, 2026 | clinicaltrials |
| NCT07584486 | Development of a New Simplified Tool to Predict LNPCPs Histology and Assess the Risk of Submucosal Invasive Cancer. The Colorectal Regular-Irregular Score(CRIS) | not yet recruiting | N/A | 764 | University Hospital, GhentOTHER | 1 | May 13, 2026 | clinicaltrials |
| NCT07585279 | A Clinical Study of Liposomal Irinotecan for Second-Line Therapy in Metastatic Colorectal Cancer | not yet recruiting | Phase 2 / Phase 3 | 408 | Hebei Medical University Fourth HospitalOTHER | 1 | May 13, 2026 | clinicaltrials |
| NCT07446387 | A Clinical Study of Iparomlimab and Tuvonralimab Combined With Bevacizumab and Alternating Triweekly CAPOX/mCAPIRI Regimen as First-line Treatment for Unresectable Advanced Colorectal Cancer | not yet recruiting | Phase 2 | 70 | Jiangsu Cancer Institute & HospitalOTHER | 1 | May 12, 2026 | clinicaltrials |
| NCT07580027 | Preoperative, Adaptive Radiotherapy Concomitant to Chemotherapy for Rectal Adenocarcinoma (Adaptive Rectal Cancer Trial 02) | not yet recruiting | N/A | 33 | IRCCS San RaffaeleOTHER | 1 | May 12, 2026 | clinicaltrials |
| NCT07519681 | Effects of Berberine on the Human Gut Microbiome | not yet recruiting | N/A | 20 | Jing-yuan Fang, MD, Ph. DOTHER | 0 | May 11, 2026 | clinicaltrials |
| NCT07574957 | Prediction of Peritoneal Dissemination of Digestive Tumors Through the Study of Circulating Tumor DNA(PREDIPER) | not yet recruiting | — | 300 | Assistance Publique - Hôpitaux de ParisOTHER | 0 | May 8, 2026 | clinicaltrials |
| NCT06258525 | SAMe in Prevention of Oxaliplatin-associated Liver Injury | not yet recruiting | Phase 2 | 30 | Cedars-Sinai Medical CenterOTHER | 1 | May 6, 2026 | clinicaltrials |
| NCT07570914 | Hepatic Arterial Infusion of Liposomal Irinotecan Plus Oxaliplatin and Capecitabine as Adjuvant Therapy for Colorectal Cancer Liver Metastases | not yet recruiting | Phase 2 | 28 | Tianjin Medical University Cancer Institute and HospitalOTHER | 0 | May 6, 2026 | clinicaltrials |
| NCT07566897 | A Phase I Study to Evaluate the Safety and Efficacy of L19IL2 in Combination With Ruxolitinib in Patients With Advanced Solid Tumors | not yet recruiting | Phase 1 | 96 | Philogen S.p.A.INDUSTRY | 1 | May 5, 2026 | clinicaltrials |
| NCT07552207 | Comparison of [68Ga]Ga-CTR-FAPI and 18F-FDG PET/MRI for Lymph Node Staging in Rectal Cancer(PKUCH-R12) | not yet recruiting | N/A | 30 | Peking University Cancer Hospital & InstituteOTHER | 0 | May 4, 2026 | clinicaltrials |
| NCT07563907 | Total Neoadjuvant Therapy With Additional Consolidation Chemotherapy Followed by Local Excision Versus Total Neoadjuvant Therapy Followed by Local Excision at Stage I Rectal Cancer(OPTION) | not yet recruiting | N/A | 292 | Seoul National University HospitalOTHER | 1 | May 4, 2026 | clinicaltrials |
| NCT06729645 | External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer(ACO/ARO/AIO-22) | not yet recruiting | N/A | 80 | University Hospital of CologneOTHER | 1 | May 1, 2026 | clinicaltrials |
| NCT05776381 | The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp | not yet recruiting | Phase 2 | 110 | Vejle HospitalOTHER | 0 | Apr 30, 2026 | clinicaltrials |
| NCT07499921 | Clinical and BIOgical Analyses of RECtal Tumors(BIOREC) | not yet recruiting | N/A | 300 | Centre Leon BerardOTHER | 1 | Apr 30, 2026 | clinicaltrials |
| NCT07381309 | Oncolytic Virus (H101) + SBRT + Chemotherapy + Targeted Therapy + Immunotherapy for Unresectable CRLM(VVSHIP) | not yet recruiting | Phase 2 | 114 | Jun HuangOTHER | 1 | Apr 28, 2026 | clinicaltrials |
| NCT07549906 | Neoadjuvant Iparomlimab/Tuvonralimab Plus CAPEOX Versus Iparomlimab/Tuvonralimab Plus CAPEOX and Propranolol for Locally Advanced pMMR Colon Cancer: A Prospective, Single-Center, Multi-Cohort Study | not yet recruiting | Phase 2 | 45 | Sun Yat-sen UniversityOTHER | 0 | Apr 24, 2026 | clinicaltrials |
| NCT07551479 | SCRT Based iTNT vs. LCRT Based TNT for MSS Locally Advanced Rectal Cancer(TORCH-STAR) | not yet recruiting | Phase 3 | 612 | Fudan UniversityOTHER | 1 | Apr 24, 2026 | clinicaltrials |
| NCT07543848 | A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course Radiotherapy, and XELOX Chemotherapy as Total Neoadjuvant Treatment for Locally Advanced (cT1-3N0M0) Rectal Cancer | not yet recruiting | Phase 2 | 20 | Chongqing University Cancer HospitalOTHER | 1 | Apr 22, 2026 | clinicaltrials |
Data updated 22 days agoSource updated Jun 16, 2026source: clinicaltrials