Cancer
Malignant Kidney Neoplasm
CI-CAN-00003171Explore in graph →
Top-level453 active trials17 approved drugs80 evidence items
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Cancer
CI-CAN-00003171Explore in graph →
Genomics
25 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
451 cases with simple somatic mutation data · 538 cases total · 2026-01-07 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | VHL | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 225 |
| 451 |
| 49.9% |
| cbioportal |
| 2 | PBRM1 | Ssm | 133 | 451 | 29.5% | cbioportal |
| 3 | MUC4 | Ssm | 77 | 451 | 17.1% | cbioportal |
| 4 | TTN | Ssm | 71 | 451 | 15.7% | cbioportal |
| 5 | MUC16 | Ssm | 58 | 451 | 12.9% | cbioportal |
| 6 | SETD2 | Ssm | 51 | 451 | 11.3% | cbioportal |
| 7 | BAP1 | Ssm | 40 | 451 | 8.9% | cbioportal |
| 8 | MTOR | Ssm | 32 | 451 | 7.1% | cbioportal |
| 9 | FBN2 | Ssm | 30 | 451 | 6.7% | cbioportal |
| 10 | XIRP2 | Ssm | 28 | 451 | 6.2% | cbioportal |
| 12 | KDM5C | Ssm | 27 | 451 | 6% | cbioportal |
| 11 | DNAH3 | Ssm | 27 | 451 | 6% | cbioportal |
| 13 | HMCN1 | Ssm | 26 | 451 | 5.8% | cbioportal |
| 16 | TSHZ3 | Ssm | 25 | 451 | 5.5% | cbioportal |
| 14 | ARAP3 | Ssm | 25 | 451 | 5.5% | cbioportal |
| 15 | ARID1A | Ssm | 25 | 451 | 5.5% | cbioportal |
| 17 | SSH2 | Ssm | 24 | 451 | 5.3% | cbioportal |
| 21 | VWF | Ssm | 23 | 451 | 5.1% | cbioportal |
| 18 | AKAP9 | Ssm | 23 | 451 | 5.1% | cbioportal |
| 20 | SPEN | Ssm | 23 | 451 | 5.1% | cbioportal |
| 19 | NAV3 | Ssm | 23 | 451 | 5.1% | cbioportal |
| 23 | CD4 | Ssm | 22 | 451 | 4.9% | cbioportal |
| 26 | PDZD2 | Ssm | 22 | 451 | 4.9% | cbioportal |
| 22 | ABCA1 | Ssm | 22 | 451 | 4.9% | cbioportal |
| 24 | GRIN2B | Ssm | 22 | 451 | 4.9% | cbioportal |
| 25 | MAP1B | Ssm | 22 | 451 | 4.9% | cbioportal |
| 37 | SSX3 | Ssm | 21 | 451 | 4.7% | cbioportal |
| 33 | KMT2D | Ssm | 21 | 451 | 4.7% | cbioportal |
| 34 | LRP1 | Ssm | 21 | 451 | 4.7% | cbioportal |
| 28 | DCHS1 | Ssm | 21 | 451 | 4.7% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07