Cancer
Malignant Esophageal Neoplasm
CI-CAN-00001127Explore in graph →
Top-level518 active trials6 approved drugs12 evidence items
Loading cancer entity…
Cancer
CI-CAN-00001127Explore in graph →
Clinical trials
1,926 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (169)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT03132922 | MAGE-A4ᶜ¹º³²T for Multi-Tumor | active not recruiting | Phase 1 | 71 | USWM CT, LLCINDUSTRY | 2 | Jun 4, 2026 | clinicaltrials |
| NCT04566393 | Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies | available | — | — | xCuresINDUSTRY | 1 | Jun 4, 2026 | clinicaltrials |
| NCT06339619 |
| Combination Immunotherapy of Adebrelimab With Apatinib and Tegafur, Gimeracil and Oteracil Potassium Capsules for Immune Rechallenge Therapy in Esophageal Squamous Cell Carcinoma |
| recruiting |
| Phase 2 |
| 32 |
| Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityOTHER |
| 1 |
| Jun 4, 2026 |
| clinicaltrials |
| NCT01196390 | Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer | completed | Phase 3 | 203 | National Cancer Institute (NCI)NIH | 1 | Jun 2, 2026 | clinicaltrials |
| NCT06071845 | Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples(SOS4C) | recruiting | N/A | 450 | Mayo ClinicOTHER | 1 | Jun 2, 2026 | clinicaltrials |
| NCT06914011 | Circulating Tumor DNA MRD-Guided Adjuvant Therapy for Curatively Resected Locally Advanced Esophageal Squamous Cell Carcinoma(MRD2START) | not yet recruiting | Phase 3 | 172 | Asan Medical CenterOTHER | 0 | Jun 2, 2026 | clinicaltrials |
| NCT07621601 | A Study of HS-20093 in Patients With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) | not yet recruiting | Phase 3 | 494 | Hansoh BioMedical R&D CompanyINDUSTRY | 0 | Jun 2, 2026 | clinicaltrials |
| NCT05704530 | Liquid Biopsies in Esophageal Cancer | recruiting | N/A | 248 | Universitaire Ziekenhuizen KU LeuvenOTHER | 1 | Jun 1, 2026 | clinicaltrials |
| NCT07618910 | Retlirafusp Alfa Plus Chemotherapy as Neoadjuvant Therapy for Thoracic ESCC | not yet recruiting | Phase 2 | 33 | Tang-Du HospitalOTHER | 1 | Jun 1, 2026 | clinicaltrials |
| NCT07162506 | DCRT vs. Surgery in Resectable ESCC Patient Achiving cCR/PR After nCI | recruiting | Phase 2 | 120 | Tianjin Medical University Cancer Institute and HospitalOTHER | 1 | May 29, 2026 | clinicaltrials |
| NCT07452601 | Time-of-Day of Immunotherapy Infusion in Neoadjuvant Immunochemotherapy for Thoracic ESCC | recruiting | Phase 2 | 90 | Tang-Du HospitalOTHER | 1 | May 28, 2026 | clinicaltrials |
| NCT07605312 | AI-Based Risk Prediction Model for Upper Digestive Tract Cancer | not yet recruiting | — | 10,000 | National Taiwan University HospitalOTHER | 0 | May 28, 2026 | clinicaltrials |
| NCT04183218 | Characterizing Chemo-Radiotherapy Treatment-Related Cardiac Changes | completed | — | 24 | Mayo ClinicOTHER | 1 | May 27, 2026 | clinicaltrials |
| NCT05910827 | A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell Cancers | recruiting | Phase 1 / Phase 2 | 398 | Hummingbird BioscienceINDUSTRY | 5 | May 27, 2026 | clinicaltrials |
| NCT06872515 | Impact of Prehabilitation in Oncology Via Exercise- Esophageal (IMPROVE-Esophageal) | recruiting | N/A | 20 | University of PittsburghOTHER | 1 | May 26, 2026 | clinicaltrials |
| NCT07605663 | an AI-Driven Four-Tier Invasion Depth Classification for Early Esophageal Cancer | active not recruiting | — | 890 | Fudan UniversityOTHER | 1 | May 26, 2026 | clinicaltrials |
| NCT04494009 | PD-1 Inhibitor INCMGA00012 as Consolidation Therapy After Definitive Concurrent Chemoradiotherapy(RHAPSODY) | active not recruiting | Phase 2 | 110 | Asan Medical CenterOTHER | 1 | May 22, 2026 | clinicaltrials |
| NCT06067438 | Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer | recruiting | Phase 2 | 90 | OHSU Knight Cancer InstituteOTHER | 1 | May 22, 2026 | clinicaltrials |
| NCT06238479 | A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors(EXCEED) | active not recruiting | Phase 1 | 490 | Eli Lilly and CompanyINDUSTRY | 7 | May 22, 2026 | clinicaltrials |
| NCT06437288 | Hematoporphyrin Photodynamic Therapy for Esophageal Cancer | enrolling by invitation | Phase 4 | 198 | Sun Yat-sen UniversityOTHER | 1 | May 22, 2026 | clinicaltrials |
| NCT06558786 | Registry for Esophageal and Gastroesophageal Junction Cancer | recruiting | — | 50 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | May 22, 2026 | clinicaltrials |
| NCT06181656 | Serologic Response to Pneumococcal Vaccination Among Esophageal Cancer Patients With High Grade Lymphopenia After Chemoradiation | recruiting | — | 80 | M.D. Anderson Cancer CenterOTHER | 1 | May 20, 2026 | clinicaltrials |
| NCT07038629 | Chemoradiation Plus Iparomlimab Consolidation in Older With ESCC | recruiting | Phase 2 | 52 | Tianjin Medical University Cancer Institute and HospitalOTHER | 1 | May 20, 2026 | clinicaltrials |
| NCT07205731 | Phase II Study Evaluating Safety and Efficacy of Tislelizumab for Elderly Patients Unfit for Chemotherapy, With Advanced Esophageal Squamous-cell Carcinoma(SAFE ESO) | recruiting | Phase 2 | 95 | University Hospital, Clermont-FerrandOTHER | 1 | May 20, 2026 | clinicaltrials |
| NCT04846309 | Hypoxia Imaging for Esophageal Cancer to Guide Personalized Radiation Therapy(PIONEER) | recruiting | Phase 1 | 16 | University of UtahOTHER | 1 | May 19, 2026 | clinicaltrials |
| NCT06414902 | 18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer | recruiting | Phase 1 | 60 | M.D. Anderson Cancer CenterOTHER | 1 | May 19, 2026 | clinicaltrials |
| NCT07595770 | Adebrelimab Combined With Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Carcinoma(ANCRE) | recruiting | Phase 2 | 37 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityOTHER | 1 | May 19, 2026 | clinicaltrials |
| NCT04984733 | Temozolomide + Nivolumab in MGMT Methylated Oesophagogastric Cancer(ELEVATE) | completed | Phase 2 | 13 | University of SouthamptonOTHER | 1 | May 18, 2026 | clinicaltrials |
| NCT06769113 | A Phase II Clinical Study to Evaluate HLX43 in Patients With Recurrent/Metastatic ESCC Failed or Intolerance to Standard Therapy | recruiting | Phase 2 | 102 | Shanghai Henlius BiotechINDUSTRY | 1 | May 18, 2026 | clinicaltrials |
| NCT07594548 | Futibatinib With Paclitaxel and Ramucirumab for the Treatment of Locally Advanced or Unresectable Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma | not yet recruiting | Phase 1 | 18 | Northwestern UniversityOTHER | 1 | May 18, 2026 | clinicaltrials |
| NCT04776837 | Predicting Disease Progression and/or Recurrence in Cancer | completed | — | 159 | Massachusetts General HospitalOTHER | 1 | May 15, 2026 | clinicaltrials |
| NCT05698992 | Rehabilitation and Recovery for Persons With Esophageal or Gastric Cancer | recruiting | — | 100 | Region SkaneOTHER | 1 | May 15, 2026 | clinicaltrials |
| NCT06251973 | A Study of agenT-797 in Combination With Botensilimab, Balstilimab, Ramucirumab, and Paclitaxel for People With Esophageal, Gastric, or Gastro-esophageal Junction Cancer | active not recruiting | Phase 2 | 20 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | May 15, 2026 | clinicaltrials |
| NCT07432295 | Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2) | recruiting | Phase 2 | 180 | I-Mab Biopharma US LimitedINDUSTRY | 3 | May 14, 2026 | clinicaltrials |
| NCT04314401 | National Cancer Institute "Cancer Moonshot Biobank" | active not recruiting | — | 1,600 | National Cancer Institute (NCI)NIH | 2 | May 13, 2026 | clinicaltrials |
| NCT04550260 | Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC(KUNLUN) | active not recruiting | Phase 3 | 640 | AstraZenecaINDUSTRY | 16 | May 13, 2026 | clinicaltrials |
| NCT06673329 | Brodalumab in the Treatment of Immune-Related Adverse Events | recruiting | Phase 1 | 11 | Brian Henick, MDOTHER | 1 | May 13, 2026 | clinicaltrials |
| NCT07584577 | Evaluation of the Administration of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in the Context of Esophageal or Stomach Cancer(FREJENO) | recruiting | — | 670 | University Hospital, BordeauxOTHER | 1 | May 13, 2026 | clinicaltrials |
| NCT07085091 | A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors | recruiting | Phase 1 | 170 | ALX Oncology Inc.INDUSTRY | 1 | May 12, 2026 | clinicaltrials |
| NCT05667298 | Organ-Preserving Endoscopic Resection & Adjuvant RADIO-immuno-chemotherapy for Esophageal Cancer(OPERARADIO) | active not recruiting | Phase 1 | 11 | University of ManitobaOTHER | 1 | May 11, 2026 | clinicaltrials |
| NCT06290505 | A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study(PALEO) | recruiting | Phase 2 | 54 | Australasian Gastro-Intestinal Trials GroupNETWORK | 2 | May 8, 2026 | clinicaltrials |
| NCT07573397 | A Prospective Study of Tumor-specific Tpex in Negative Lymph Nodes for Predicting Pathological Complete Response to Neoadjuvant PD 1 Therapy in Esophageal Cancer | not yet recruiting | — | 88 | Fudan UniversityOTHER | 0 | May 7, 2026 | clinicaltrials |
| NCT06239194 | Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors | recruiting | Phase 1 / Phase 2 | 285 | ModeX Therapeutics, An OPKO Health CompanyINDUSTRY | 1 | May 6, 2026 | clinicaltrials |
| NCT06862479 | Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences(ES-LCCE-UDFM)(ES-LCCE-UDFM) | enrolling by invitation | — | 180 | Unidade Local de Saúde Santa MariaOTHER_GOV | 1 | May 6, 2026 | clinicaltrials |
| NCT07567716 | Infiltration Pattern of Locally Advanced ESCC | enrolling by invitation | — | 30 | Shanghai Chest HospitalOTHER | 1 | May 5, 2026 | clinicaltrials |
| NCT04929015 | Peritoneal Carcinomatosis Leveraging ctDNA Guided Treatment in GI Cancer Study (PERICLES Study) | suspended | N/A | 30 | Rutgers, The State University of New JerseyOTHER | 1 | May 4, 2026 | clinicaltrials |
| NCT04986293 | CPAP or BiPAP for Motion Mitigation During Radiotherapy(SISTER) | recruiting | N/A | 31 | University Medical Center GroningenOTHER | 1 | May 4, 2026 | clinicaltrials |
| NCT07307560 | High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients | recruiting | N/A | 600 | Zhejiang UniversityOTHER | 1 | May 4, 2026 | clinicaltrials |
Data updated 23 days agoSource updated Jun 4, 2026source: clinicaltrials