Cancer Family
Malignant Digestive System Neoplasm
CI-CAN-00000229Explore in graph →
4,262 active trials43 approved drugs556 evidence items
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Cancer Family
CI-CAN-00000229Explore in graph →
Genomics
96 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
138 cases with simple somatic mutation data · 138 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 125 |
| 138 |
| 90.6% |
| cbioportal |
| 2 | TP53 | Ssm | 111 | 138 | 80.4% | cbioportal |
| 3 | KRAS | Ssm | 76 | 138 | 55.1% | cbioportal |
| 4 | PIK3CA | Ssm | 27 | 138 | 19.6% | cbioportal |
| 5 | SMAD4 | Ssm | 17 | 138 | 12.3% | cbioportal |
| 6 | AMER1 | Ssm | 12 | 138 | 8.7% | cbioportal |
| 7 | FBXW7 | Ssm | 12 | 138 | 8.7% | cbioportal |
| 8 | CTNNB1 | Ssm | 10 | 138 | 7.2% | cbioportal |
| 9 | ERBB3 | Ssm | 8 | 138 | 5.8% | cbioportal |
| 11 | PTPRS | Ssm | 7 | 138 | 5.1% | cbioportal |
| 10 | EPHA5 | Ssm | 7 | 138 | 5.1% | cbioportal |
| 14 | CREBBP | Ssm | 6 | 138 | 4.3% | cbioportal |
| 12 | ASXL1 | Ssm | 6 | 138 | 4.3% | cbioportal |
| 13 | BRAF | Ssm | 6 | 138 | 4.3% | cbioportal |
| 15 | AR | Ssm | 5 | 138 | 3.6% | cbioportal |
| 18 | ERBB2 | Ssm | 5 | 138 | 3.6% | cbioportal |
| 17 | EPHB1 | Ssm | 5 | 138 | 3.6% | cbioportal |
| 19 | GRIN2A | Ssm | 5 | 138 | 3.6% | cbioportal |
| 16 | ATRX | Ssm | 5 | 138 | 3.6% | cbioportal |
| 46 | TSHR | Ssm | 4 | 138 | 2.9% | cbioportal |
| 20 | EPHA6 | Ssm | 4 | 138 | 2.9% | cbioportal |
| 21 | EPHA7 | Ssm | 4 | 138 | 2.9% | cbioportal |
| 22 | EPHB4 | Ssm | 4 | 138 | 2.9% | cbioportal |
| 23 | ERBB4 | Ssm | 4 | 138 | 2.9% | cbioportal |
| 24 | FLCN | Ssm | 4 | 138 | 2.9% | cbioportal |
| 25 | FLT1 | Ssm | 4 | 138 | 2.9% | cbioportal |
| 26 | GNAS | Ssm | 4 | 138 | 2.9% | cbioportal |
| 27 | JAK1 | Ssm | 4 | 138 | 2.9% | cbioportal |
| 28 | KMT2D | Ssm | 4 | 138 | 2.9% | cbioportal |
| 29 | MAGI2 | Ssm | 4 | 138 | 2.9% | cbioportal |
Data updated 22 days agoSource updated 2026-01-06