Malignant Digestive System Neoplasm

In an in vitro study, NCI-H508 cell lines expressing an ERBB2 L755S mutation demonstrated resistance to cetuximab treatment (IC50 > 200 ug/mL) compared with NCI-H508 cells expressing ERBB2 wild type (… (full text at CIViC)

PMID 26243863 · Kavuri et al., 2015 · Open in CIViC

Patient was a 35 year old male who was treated with pseudoadjuvant FOLFOX chemotherapy. Patient relapsed and was found to have an ERBB2 L755S kinase domain mutation along with mutations in APC and BRA… (full text at CIViC)

PMID 27626067 · Aung et al., 2016 · Open in CIViC

Colon cancer patient derived xenografts with HER2 mutations are sensitive to HER2 targeted drugs and the greatest tumor reduction was seen with the combination of a tyrosine kinase inhibitor with tras… (full text at CIViC)

PMID 26243863 · Kavuri et al., 2015 · Open in CIViC

KRAS G12D-transformed HPNE cells with lentiviral vectors containing the variant significantly increased colony formation in number and size in soft agar compared to infected HPNE cells with the varian… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

bp] In an in vitro study, NCI-H508 cell lines expressing an ERBB2 L866M mutation demonstrated resistance to cetuximab treatment compared to NCI-H508 cells expressing ERBB2 wild-type. Resistance was de… (full text at CIViC)

PMID 26243863 · Kavuri et al., 2015 · Open in CIViC

Colon cancer patient derived xenografts with HER2 mutations are sensitive to HER2 targeted drugs and the greatest tumor reduction was seen with the combination of a tyrosine kinase inhibitor with tras… (full text at CIViC)

PMID 26243863 · Kavuri et al., 2015 · Open in CIViC

In this clinical study of 38 patients with colorectal cancer (CRC), 10 had CRC with ERBB2/ERBB3 mutation, and were treated with a combination of Pertuzumab and Trastuzumab. A DC of 10% and OR of 0% we… (full text at CIViC)

PMID 36315917 · Gupta et al., 2022 · Open in CIViC

HER2 (ERBB2) overexpressing cell lines were generated by lentiviral transduction of HER2 into three colorectal carcinoma cell lines. HER2 overexpressing cell lines were found to be resistant to cetux… (full text at CIViC)

PMID 26296355 · Leto et al., 2015 · Open in CIViC

HER2 (ERBB2) overexpressing cell lines were generated by lentiviral transduction of HER2 into three colorectal carcinoma cell lines. Mouse xenografts of NCI-H508-HER2 cells were treated with single a… (full text at CIViC)

PMID 26296355 · Leto et al., 2015 · Open in CIViC

HPNE cells infected with lentiviral vectors containing the variant did show significant phosphorylation of ERBB2 (Supplementary Figure 1) compared to WT (Figure 2A and B). The variant also exhibits an… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

HPNE cells infected with lentiviral vectors containing the variant did show significant phosphorylation of ERBB2 (Supplementary Figure 1) compared to WT (Figure 2A and B). The variant also exhibits an… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

In a retrospective cohort of gastric or gastroesophageal junction adenocarcinoma (n = 3116; ERBB2 R678Q n = 40), ERBB2 R678Q did not show a significant association with resistance to nivolumab-contain… (full text at CIViC)

PMID 40699829 · Suzuki et al., 2025 · Open in CIViC

KRAS G12D-transformed HPNE cells with lentiviral vectors containing the variant significantly increased colony formation in number and size in soft agar compared to infected HPNE cells with the varian… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

HPNE cells infected with lentiviral vectors containing the variant did show significant phosphorylation of ERBB2 (Supplementary Figure 1) compared to WT (Figure 2A and B). The variant also exhibits an… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

bp]In an in vitro study, NCI-H508 cell lines expressing an ERBB2 S310F mutation demonstrated resistance to cetuximab treatment, compared to NCI-H508 cells expressing ERBB2 wild-type. Resistance was de… (full text at CIViC)

PMID 26243863 · Kavuri et al., 2015 · Open in CIViC

Colon cancer patient derived xenografts with HER2 mutations are sensitive to HER2 targeted drugs and the greatest tumor reduction was seen with the combination of a tyrosine kinase inhibitor with tras… (full text at CIViC)

PMID 26243863 · Kavuri et al., 2015 · Open in CIViC

HPNE cells infected with lentiviral vectors containing the variant did show significant phosphorylation of ERBB2 (Supplementary Figure 1) compared to WT (Figure 2A and B). The variant also exhibits an… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

HPNE cells infected with lentiviral vectors containing the variant did show significant phosphorylation of ERBB2 (Supplementary Figure 1) compared to WT (Figure 2A and B). The variant also exhibits an… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

In an in vitro study, NCI-H508 cell lines expressing an ERBB2 V777L mutation demonstrated resistance to cetuximab treatment (IC50 >200 ug/ml) compared to NCI-H508 cells expressing ERBB2 wild-type (IC5… (full text at CIViC)

PMID 26243863 · Kavuri et al., 2015 · Open in CIViC

When tested in MIAPaCa2 (PDAC cell line and KRAS G12C) cells, Neratinib and ARS-1620 strongly inhibit AKT and MAPK phosphorylation (Figure 6F). Also, MIAPaCa2 cell line with the variant in exposure to… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

KRAS G12D-transformed HPNE cells with lentiviral vectors containing the variant significantly increased colony formation in number and size in soft agar compared to infected HPNE cells with the varian… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

HPNE cells infected with lentiviral vectors containing the variant did show significant phosphorylation of ERBB2 (Supplementary Figure 1) compared to WT (Figure 2A and B). The variant also exhibits an… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

bp]In an in vitro study, DiFi and NCI-H508 cell lines expressing an ERBB2 V842I mutation demonstrated resistance to cetuximab treatment, compared to DiFi and NCI-H508 cells expressing ERBB2 wild-type.… (full text at CIViC)

PMID 26243863 · Kavuri et al., 2015 · Open in CIViC

Neratinib suppresses anchorage-independent growth in transduced HPNE cells with the variant in a concentration-dependent manner (Figure 6B–C) with complete inhibition at a concentration of 0.5 µM (Fig… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

KRAS G12D-transformed HPNE cells with lentiviral vectors containing the variant significantly increased colony formation in number and size in soft agar compared to infected HPNE cells with the varian… (full text at CIViC)

PMID 31046123 · Li et al., 2020 · Open in CIViC

In an in vitro study, an esophageal squamous cell carcinoma (ESCC) cell line KYSE150 expressing ERBB3 (HER3) D297Y mutation was associated with insensitivity to cetuximab, afatinib, and erlotinib trea… (full text at CIViC)

PMID 27207775 · Nakamura et al., 2016 · Open in CIViC

In mice xenografts expressing ERBB3 (HER3) the combination of ERBB2 (HER2) and ERBB3 inhibitors pertuzumab and 9F7-F11enhanced tumor inhibition and the median survival time. Sensitivity to single-agen… (full text at CIViC)

PMID 25216528 · Thomas et al., 2014 · Open in CIViC

High expression of ERBB3 (her3) was associated with shorter overall survival (OS) from Cetuximab treatment in patients with metastatic colorectal cancer. Gene expression measures (qRT-PCR) were availa… (full text at CIViC)

PMID 25520391 · Cushman et al., 2015 · Open in CIViC

ERCC6 was knocked down using shRNA in HCT116 and DLD1 human colorectal cancer (CRC) cell lines, which made both cell lines more sensitive to 5-FU. To assess whether ERCC6 influences chemosensitivity i… (full text at CIViC)

PMID 28665687 · Zhao et al., 2017 · Open in CIViC

226 cetuximab-treated patients with CRC were analyzed for mRNA expression of EGFR and its ligands. Favorable predictors in a multivariate analysis were high AREG mRNA in KRAS wild type tumours, high E… (full text at CIViC)

PMID 23374602 · Pentheroudakis et al., 2013 · Open in CIViC

Prospectively planned retrospective biomarker study in archived tumor tissue from 323 patients from the PICCOLO trial (panitumumab plus irinotecan in CRC patients with KRAS wt). Tumors were classified… (full text at CIViC)

PMID 26867820 · Seligmann et al., 2016 · Open in CIViC

A patient with cholangiocarcinoma who has initially undergone surgical resection progressed on gemcitabine and cisplatin. He subsequently received pegylated hyaluroniade (PEGPH20) in an investigationa… (full text at CIViC)

PMID 24550739 · Borad et al., 2014 · Open in CIViC

An ERRFI1 (E384X) was detected in a patient with metastatic, recurrent/refractory cholangiocarcinoma (allelic fraction 11%) without any mutations or amplifications in other EGFR signaling members such… (full text at CIViC)

PMID 24550739 · Borad et al., 2014 · Open in CIViC

In vitro studies in KRAS G12V pancreatic cancer cells (PATU8902) showed that overexpression of ETV1 reduced sensitivity to trametinib.

PMID 28178529 · Wang et al., 2017 · Open in CIViC

In vitro studies in KRAS G12V pancreatic cancer cells (PATU8902) showed that overexpression of ETV4 reduced sensitivity to trametinib.

PMID 28178529 · Wang et al., 2017 · Open in CIViC

In vitro studies in KRAS G12V pancreatic cancer cells (PATU8902) showed that overexpression of ETV5 reduced sensitivity to trametinib.

PMID 28178529 · Wang et al., 2017 · Open in CIViC

The rs3757441 variant in Intron 6 of EZH2 (C/C versus C/T or T/T) was significantly correlated with lower progression free survival and overall survival in patients with metastatic Colorectal Cancer (… (full text at CIViC)

PMID 21926398 · Crea et al., 2012 · Open in CIViC

In the pancreatic cell lines PL11 (FANCC homozygous deletion) and Hs766T (FANCG-mutated), sensitivity to DNA cross-linking agents was observed. PL11 cells (empty vector transduced) were more sensitive… (full text at CIViC)

PMID 16243825 · van der Heijden et al., 2005 · Open in CIViC

In an in vitro study of 16 cancer cell lines, FBXW7 (FBW7) mutant colorectal cancer cell lines (n=8), including SNU-C2B cell line harboring FBW7 G579W mutation, were associated with resistance to rego… (full text at CIViC)

PMID 27399335 · Tong et al., 2017 · Open in CIViC