Subtype
Malignant Biliary Tract Neoplasm
CI-CAN-00003139Explore in graph →
364 active trials6 approved drugs33 evidence items
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Subtype
CI-CAN-00003139Explore in graph →
Genomics
17 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
417 cases with simple somatic mutation data · 489 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 147 |
| 417 |
| 35.3% |
| cbioportal |
| 2 | ARID1A | Ssm | 80 | 417 | 19.2% | cbioportal |
| 3 | KRAS | Ssm | 76 | 417 | 18.2% | cbioportal |
| 4 | SMAD4 | Ssm | 60 | 417 | 14.4% | cbioportal |
| 5 | SYNE1 | Ssm | 46 | 417 | 11% | cbioportal |
| 6 | MUC16 | Ssm | 44 | 417 | 10.6% | cbioportal |
| 7 | BAP1 | Ssm | 39 | 417 | 9.4% | cbioportal |
| 8 | LRP1B | Ssm | 39 | 417 | 9.4% | cbioportal |
| 9 | FSIP2 | Ssm | 37 | 417 | 8.9% | cbioportal |
| 10 | EPHA2 | Ssm | 36 | 417 | 8.6% | cbioportal |
| 11 | PCLO | Ssm | 36 | 417 | 8.6% | cbioportal |
| 13 | SACS | Ssm | 34 | 417 | 8.2% | cbioportal |
| 12 | CSMD3 | Ssm | 34 | 417 | 8.2% | cbioportal |
| 14 | APC | Ssm | 33 | 417 | 7.9% | cbioportal |
| 15 | RYR2 | Ssm | 32 | 417 | 7.7% | cbioportal |
| 16 | OBSCN | Ssm | 31 | 417 | 7.4% | cbioportal |
| 18 | KMT2D | Ssm | 30 | 417 | 7.2% | cbioportal |
| 17 | HMCN1 | Ssm | 30 | 417 | 7.2% | cbioportal |
| 20 | KMT2C | Ssm | 29 | 417 | 7% | cbioportal |
| 21 | PBRM1 | Ssm | 29 | 417 | 7% | cbioportal |
| 19 | ELF3 | Ssm | 29 | 417 | 7% | cbioportal |
| 22 | LRP2 | Ssm | 28 | 417 | 6.7% | cbioportal |
| 23 | MUC6 | Ssm | 28 | 417 | 6.7% | cbioportal |
| 24 | FAT3 | Ssm | 27 | 417 | 6.5% | cbioportal |
| 25 | ARID2 | Ssm | 25 | 417 | 6% | cbioportal |
| 30 | SPTA1 | Ssm | 24 | 417 | 5.8% | cbioportal |
| 28 | NEB | Ssm | 24 | 417 | 5.8% | cbioportal |
| 26 | ADGRV1 | Ssm | 24 | 417 | 5.8% | cbioportal |
| 29 | PLEC | Ssm | 24 | 417 | 5.8% | cbioportal |
| 27 | CSMD1 | Ssm | 24 | 417 | 5.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-06