Lung Sarcomatoid Carcinoma

A 74-year-old woman with stage II Pulmonary Sarcomatoid Carcinoma (PSC) was treated with neoadjuvant platinum/taxane chemotherapy with no improvement. Chemotherapy was stopped due to resistance and po… (full text at CIViC)

PMID 26215952 · Liu et al., 2016 · Open in CIViC

A study of 687 patients with non-small-cell lung cancer were tested for MET exon splicing mutation. In 18 cases with MET exon 14 skipping mutations, 2.6% had adenocarcinoma, 4.8% had adenosquamous cel… (full text at CIViC)

PMID 26847053 · Tong et al., 2016 · Open in CIViC

A 65-year old male (non-smoker) presented with advanced sarcomatoid non-small-cell lung cancer harboring a MET exon 14 skipping mutation with elevated PDL1 levels (tumor proportion score of 80%). Afte… (full text at CIViC)

PMID 35871685 · Gonugunta et al., 2022 · Open in CIViC

A 58-year old male (non-smoker/non-drinker) was diagnosed with metastatic adenocarcinoma with sarcomatoid components. A tissue sample revealed a MET exon 14 skipping mutation and the patient was treat… (full text at CIViC)

PMID 35110965 · Gu et al., 2022 · Open in CIViC

A 61-year old male (non-smoker) was diagnosed with sarcomatoid non-small-cell lung cancer (CK+, TTF1+, and vimentin+). Genomic profiling showed two MET alterations that showed exon 14 skipping mutatio… (full text at CIViC)

PMID 26709483 · Lee et al., 2015 · Open in CIViC

A 83-year old woman presented with sarcomatoid squamous cell carcinoma. Next-generation sequencing revealed a MET exon 14 skipping mutation (c.3028+3A>G) and the patient was treated with crizotinib (2… (full text at CIViC)

PMID 36147925 · Sun et al., 2022 · Open in CIViC