Intermediate Soft Tissue Neoplasm of Uncertain Differentiation

Intermediate Soft Tissue Neoplasm of Uncertain Differentiation — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items (4 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CREB1 Fusion4
(diagnostic)	Angiomatoid Fibrous Histiocytoma	Diagnostic	B	Supports Positive	3	accepted	EID12852 In this study, the authors analyzed 14 cases of angiomatoid fibrous histiocytoma (AFH). The EWSR1::CREB1 fusion associated with t(2;22)(q33;q12) was detected in 13 of 14 tumors by dual‑color and four‑… (full text at CIViC) PMID 18094413 · Rossi et al., 2007 · Open in CIViC	civic
〃	Angiomatoid Fibrous Histiocytoma	Diagnostic	B	Supports Positive	3	accepted	EID12855 In this study, the authors analyzed 9 cases of angiomatoid fibrous histiocytoma (AFH). The EWSR1::CREB1 fusion was identified as the predominant molecular alteration, detected in 8 of 9 tumors by RT‑P… (full text at CIViC) PMID 17724745 · Antonescu et al., 2007 · Open in CIViC	civic
〃	Angiomatoid Fibrous Histiocytoma	Diagnostic	C	Supports Positive	3	accepted	EID12853 In this study, the authors report a 34‑year-old patient with angiomatoid fibrous histiocytoma (AFH) who initially presented with a pulmonary nodule and a 4th‑rib lesion and subsequently developed meta… (full text at CIViC) PMID 39845329 · Feng et al., 2024 · Open in CIViC	civic
(prognostic)	Angiomatoid Fibrous Histiocytoma	Prognostic	C	Supports Poor Outcome	1	rejected	EID12854 The EWSR1::CREB1 fusion associated with t(2;22)(q33;q12) represents a defining diagnostic alteration in angiomatoid fibrous histiocytoma (AFH); in this case, a 34‑year‑old patient initially presented … (full text at CIViC) PMID 39845329 · Feng et al., 2024 · Open in CIViC	civic

Data updated 10 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.