CREB1 Fusion

CI-VAR-00001519Explore in graph →CIViC 5479

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Angiomatoid Fibrous Histiocytoma4
EWSR1::CREB1 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID12852 In this study, the authors analyzed 14 cases of angiomatoid fibrous histiocytoma (AFH). The EWSR1::CREB1 fusion associated with t(2;22)(q33;q12) was detected in 13 of 14 tumors by dual‑color and four‑… (full text at CIViC) PMID 18094413 · Rossi et al., 2007 · Open in CIViC	civic
EWSR1::CREB1 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID12855 In this study, the authors analyzed 9 cases of angiomatoid fibrous histiocytoma (AFH). The EWSR1::CREB1 fusion was identified as the predominant molecular alteration, detected in 8 of 9 tumors by RT‑P… (full text at CIViC) PMID 17724745 · Antonescu et al., 2007 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.