High Grade B-Cell Lymphoma with MYC and BCL2 Rearrangements

High Grade B-Cell Lymphoma with MYC and BCL2 Rearrangements — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

2 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BCL2 Translocation1
(diagnostic)	Diagnostic	A	Supports Positive	4	submitted	EID11810 The combination of these genetic features are diagnostic for this newly defined entity as per the latest ICC and WHO guidelines PMID 35653592 · Campo et al., 2022 · Open in CIViC	civic
BCL2 Translocation + MYC TranslocationMYC BCL21
(diagnostic)	Diagnostic	A	Supports Positive	4	submitted	EID11811 MYC and BCL2 rearrangements together are defining diagnostic features of this new entity PMID 35653592 · Campo et al., 2022 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.