Fibrolamellar Carcinoma — Variants & evidence

Fibrolamellar Carcinoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PRKACA Fusion3
(diagnostic)	Diagnostic	B	Supports Positive	5	accepted	EID532 RT-PCR and FISH assays were developed for the detection of rearrangements of the PRKACA locus. A total of 106 primary liver tumors were studied by RT-PCR (26 fibrolamellar carcinomas, 25 conventional … (full text at CIViC) PMID 25698061 · Graham et al., 2015 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID405 A head-to-tail in-frame fusion between exon1 of DNAJB1 and exon2 of PRKACA resulting from a ~400kb deletion was observed in 100% (15/15) fibrolamellar hepatocellular carcinomas examined. The fusion wa… (full text at CIViC) PMID 24578576 · Honeyman et al., 2014 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID754 The DNAJB1-PRKACA fusion was detected in 79% (58/73) of fibrolamellar hepatocellular carcinomas assayed. PMID 25557953 · Cornella et al., 2015 · Open in CIViC	civic

Data updated 18 minutes agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.