Esophageal Adenocarcinoma — Genomics

Esophageal Adenocarcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

4 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Esophageal Adenocarcinoma (DFCI, Nat Genet 2013) esca_broadDFCI

151 cases with simple somatic mutation data · 151 cases total · 2026-01-07 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	106	151	70.2%	cbioportal
2	TTN	Ssm	81	151	53.6%	cbioportal
3	MUC16	Ssm	41	151	27.2%	cbioportal
4	SYNE1	Ssm	36	151	23.8%	cbioportal
5	LRP1B	Ssm	34	151	22.5%	cbioportal
6	FLG	Ssm	33	151	21.9%	cbioportal
7	SPTA1	Ssm	32	151	21.2%	cbioportal
8	PCLO

Data updated 22 days agoSource updated 2026-01-07

Esophageal Adenocarcinoma (TCGA GDC, 2025) esca_tcga_gdcTCGA GDC

185 cases with simple somatic mutation data · 186 cases total · 2026-01-13 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	156

Esophageal Adenocarcinoma (TCGA, PanCancer Atlas) esca_tcga_pan_can_atlas_2018TCGA

182 cases with simple somatic mutation data · 182 cases total · 2026-06-05 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1

Esophageal Carcinoma (TCGA, Firehose Legacy) esca_tcgaTCGA

185 cases with simple somatic mutation data · 186 cases total · 2026-01-07 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	153

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.