Desmoplastic Small Round Cell Tumor — Variants & evidence

Desmoplastic Small Round Cell Tumor — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
WT1 Fusion3
(diagnostic)	Diagnostic	B	Supports Positive	2	accepted	EID11405 In an analysis of a cohort of desmoplastic small round cell tumor, evidence of a functional EWSR1::WT1 fusion was detected in 25 of 26 cases. In these cases, the genomic breakpoints in WT1 was in in… (full text at CIViC) PMID 9738572 · Gerald et al., 1998 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	2	accepted	EID11406 In an analysis of 6 desmoplastic small round cell tumors, chimeric EWSR1::WT1 transcripts were detected in 4. The translocation resulted in an in-frame fusion of the N terminus (first 7 exons) of EWS… (full text at CIViC) PMID 7862627 · Gerald et al., 1995 · Open in CIViC	civic
〃	Diagnostic	C	Supports Positive	2	accepted	EID11407 Molecular analysis of desmoplastic small round cell tumors with recurrent translocation, t(11;22) (p13;q12) identified EWSR1 on 22q12 and WT1 on 11p13 as the genes involved in the rearrangement. Furt… (full text at CIViC) PMID 8187063 · Ladanyi et al., 1994 · Open in CIViC	civic

Data updated 2 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.