Hematologic Malignancy
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
CI-CAN-00000765Explore in graph →
Hematologic298 active trials6 approved drugs47 evidence items
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Hematologic Malignancy
CI-CAN-00000765Explore in graph →
Clinical trials
1,406 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (273)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT03939234 | Peptide Vaccination With PD-L1 and PD-L2 Peptides in Untreated Chronic Lymphatic Leukemia. | completed | Phase 2 | 19 | Lars Møller PedersenOTHER | 1 | Feb 21, 2022 | clinicaltrials |
| NCT01125176 | Alternating Thalidomide and Lenalidomide Therapy Plus Rituximab (ThRiL) as Initial Treatment for Patients With CLL(ThRiL) | completed | Phase 2 | 15 | Weill Medical College of Cornell UniversityOTHER | 1 | Jan 21, 2022 |
| clinicaltrials |
| NCT01556776 | A Study of Lenalidomide Maintenance for High-risk Patients With CLL Following First-line Therapy | completed | Phase 3 | 89 | German CLL Study GroupOTHER | 1 | Jan 5, 2022 | clinicaltrials |
| NCT02983617 | Safety and Efficacy of the Combination of Tirabrutinib and Entospletinib With and Without Obinutuzumab in Adults With Chronic Lymphocytic Leukemia (CLL) | completed | Phase 2 | 36 | Gilead SciencesINDUSTRY | 1 | Dec 21, 2021 | clinicaltrials |
| NCT02639910 | Study to Evaluate Safety and Preliminary Efficacy of Tafasitamab With Idelalisib or Venetoclax in R/R CLL/SLL Patients Pretreated With BTKi(COSMOS) | completed | Phase 2 | 24 | MorphoSys AGINDUSTRY | 6 | Dec 20, 2021 | clinicaltrials |
| NCT01889186 | A Study of the Efficacy of ABT-199 in Subjects With Relapsed/Refractory or Previously Untreated Chronic Lymphocytic Leukemia With the 17p Deletion | completed | Phase 2 | 158 | AbbVieINDUSTRY | 7 | Dec 16, 2021 | clinicaltrials |
| NCT03263637 | Study to Assess Safety, Tolerability, Pharmacokinetics and Antitumor Activity of AZD4573 in Relapsed/Refractory Haematological Malignancies | completed | Phase 1 | 44 | AstraZenecaINDUSTRY | 3 | Oct 22, 2021 | clinicaltrials |
| NCT03068416 | CD19-targeting, 3rd Generation CAR T Cells for Refractory B Cells Malignancy | completed | Phase 2 | 24 | Uppsala UniversityOTHER | 1 | Oct 20, 2021 | clinicaltrials |
| NCT01353625 | Study to Assess Safety and Tolerability of Oral CC-115 for Patients With Advanced Solid Tumors, and Hematologic Malignancies. | completed | Phase 1 | 118 | CelgeneINDUSTRY | 4 | Oct 5, 2021 | clinicaltrials |
| NCT01381692 | Bortezomib, Rituximab, and Dexamethasone With or Without Temsirolimus in Treating Patients With Untreated or Relapsed Waldenstrom Macroglobulinemia or Relapsed or Refractory Mantle Cell or Follicular Lymphoma | completed | Phase 1 / Phase 2 | 9 | National Cancer Institute (NCI)NIH | 1 | Oct 4, 2021 | clinicaltrials |
| NCT03045328 | Venetoclax and Ibrutinib in Patients With Relapsed/Refractory CLL or SLL | completed | Phase 2 | 22 | Steven E. CoutreOTHER | 1 | Sep 29, 2021 | clinicaltrials |
| NCT00772486 | A Phase Ib Study of ISF35 in Combination With Chemotherapy (FCR) in Subjects With Relapsed, Refractory, and/or 17p- CLL | completed | Phase 1 | 13 | Memgen, LLCINDUSTRY | 1 | Sep 22, 2021 | clinicaltrials |
| NCT03436524 | A Prognostic Tool for Early Stage CLL | completed | — | 4,933 | Oncology Institute of Southern SwitzerlandOTHER | 1 | Sep 16, 2021 | clinicaltrials |
| NCT02582320 | Clinical-biological Characteristics and Outcome of Chronic Lymphocytic Leukemia Under Ibrutinib-named Patient Program | completed | — | 264 | Gruppo Italiano Malattie EMatologiche dell'AdultoOTHER | 1 | Sep 13, 2021 | clinicaltrials |
| NCT00759798 | Identifying Prognostic Factors in Frontline FCR for Patients With Chronic Lymphocytic Leukemia (CLL) | completed | Phase 2 | 289 | M.D. Anderson Cancer CenterOTHER | 1 | Sep 5, 2021 | clinicaltrials |
| NCT01767766 | Evaluate the Safety and Efficacy of TGR 1202 in Patients With Relapsed or Refractory Hematologic Malignancies | completed | Phase 1 | 90 | TG Therapeutics, Inc.INDUSTRY | 1 | Aug 23, 2021 | clinicaltrials |
| NCT00546793 | Ph I/II Study of Subcutaneously Administered Veltuzumab (hA20) in NHL and CLL | completed | Phase 1 / Phase 2 | 32 | Gilead SciencesINDUSTRY | 1 | Aug 16, 2021 | clinicaltrials |
| NCT02265731 | Study Evaluating Venetoclax in Subjects With Hematological Malignancies | completed | Phase 1 / Phase 2 | 38 | AbbVieINDUSTRY | 1 | Aug 2, 2021 | clinicaltrials |
| NCT01444716 | Ofatumumab as Front-Line Therapy in Treating Elderly Participants With Chronic Lymphocytic Leukemia | completed | Phase 2 | 34 | M.D. Anderson Cancer CenterOTHER | 1 | Jul 26, 2021 | clinicaltrials |
| NCT02933320 | BI-1206 and an Anti-CD20 Antibody in Patients With CD32b Positive B-cell Lymphoma or Leukaemia | completed | Phase 1 / Phase 2 | 14 | Cancer Research UKOTHER | 1 | Jul 8, 2021 | clinicaltrials |
| NCT04950452 | Exercise Training to Promote Resilience to Chronic Lymphocytic Leukemia(HIIT-CLL) | completed | N/A | 20 | Duke UniversityOTHER | 1 | Jul 6, 2021 | clinicaltrials |
| NCT00792077 | A Pilot Study to Investigate the Effect of Cytotoxic Therapy and/or Radiotherapy on Cancer Related Sleep Disturbances in CLL and Breast Cancer Patients Experiencing Fatigue | completed | Phase 2 | 6 | M.D. Anderson Cancer CenterOTHER | 1 | Jul 1, 2021 | clinicaltrials |
| NCT01822509 | Ipilimumab or Nivolumab in Treating Patients With Relapsed Hematologic Malignancies After Donor Stem Cell Transplant | completed | Phase 1 | 71 | National Cancer Institute (NCI)NIH | 1 | Jun 24, 2021 | clinicaltrials |
| NCT02424968 | CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma | completed | Phase 2 | 18 | Robert LowskyOTHER | 1 | Jun 24, 2021 | clinicaltrials |
| NCT00378534 | Methods to Enhance the Safety and Effectiveness of Stem Cell Transplants | completed | Phase 2 | 116 | National Heart, Lung, and Blood Institute (NHLBI)NIH | 1 | Jun 16, 2021 | clinicaltrials |
| NCT01768845 | Unrelated Umbilical Cord Blood (UBC)Transplantation | completed | N/A | 34 | West Virginia UniversityOTHER | 1 | Jun 14, 2021 | clinicaltrials |
| NCT01188681 | Safety and Efficacy Study of TRU-016 Plus Bendamustine vs. Bendamustine in Relapsed Chronic Lymphocytic Leukemia | completed | Phase 1 / Phase 2 | 79 | Aptevo TherapeuticsINDUSTRY | 5 | Jun 10, 2021 | clinicaltrials |
| NCT02669017 | Study of ADCT-402 in Patients With Relapsed or Refractory B-cell Lineage Non Hodgkin Lymphoma (B-NHL) | completed | Phase 1 | 183 | ADC Therapeutics S.A.INDUSTRY | 3 | May 19, 2021 | clinicaltrials |
| NCT01716208 | Ofatumumab and Fresh Frozen Plasma in Patients With Chronic Lymphocytic Lymphoma | completed | Phase 2 | 12 | Joseph TuscanoOTHER | 1 | May 11, 2021 | clinicaltrials |
| NCT02037256 | Bortezomib and Filgrastim to Promote Stem Cell Mobilization in Patients With Non-Hodgkin Lymphoma or Multiple Myeloma | completed | N/A | 23 | Barbara Ann Karmanos Cancer InstituteOTHER | 1 | May 10, 2021 | clinicaltrials |
| NCT02129582 | Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies | completed | Phase 1 | 14 | Case Comprehensive Cancer CenterOTHER | 1 | May 7, 2021 | clinicaltrials |
| NCT01497496 | Ofatumumab/Methylprednisolone and Ofatumumab/Lenalidomide for Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) | completed | Phase 2 | 29 | H. Lee Moffitt Cancer Center and Research InstituteOTHER | 1 | Apr 27, 2021 | clinicaltrials |
| NCT00536601 | High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid Tumors | completed | N/A | 174 | Roswell Park Cancer InstituteOTHER | 1 | Apr 22, 2021 | clinicaltrials |
| NCT03041636 | Ruxolitinib Phosphate in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | completed | Phase 2 | 1 | M.D. Anderson Cancer CenterOTHER | 1 | Apr 21, 2021 | clinicaltrials |
| NCT01441882 | Dasatinib in Treating Patients With Chronic Lymphocytic Leukemia | completed | Phase 2 | 19 | OHSU Knight Cancer InstituteOTHER | 1 | Apr 8, 2021 | clinicaltrials |
| NCT03076437 | Anti-CD19 Chimeric Antigen Receptor (CAR)-Transduced T Cell Therapy for Patients With B Cell Malignancies | completed | Phase 1 / Phase 2 | 28 | Shenzhen Institute for Innovation and Translational MedicineOTHER | 1 | Mar 19, 2021 | clinicaltrials |
| NCT01659255 | Study to Evaluate the Safety and Tolerability of Tirabrutinib (ONO/GS-4059) Given as Monotherapy in Participants With Relapsed/Refractory NHL and CLL | completed | Phase 1 | 90 | Gilead SciencesINDUSTRY | 2 | Mar 16, 2021 | clinicaltrials |
| NCT01110863 | Characterization of Proliferating Compartment in B-Cell Patients and in Healthy Aging Subjects | completed | — | 90 | Northwell HealthOTHER | 1 | Mar 3, 2021 | clinicaltrials |
| NCT01110850 | Direct Measurement of Leukemic Cell Turnover (Synthesis and Removal) in Patients With Chronic Lymphocytic Leukemia (CLL) Using Deuterated Water | completed | — | 24 | Northwell HealthOTHER | 1 | Mar 2, 2021 | clinicaltrials |
| NCT02948283 | Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia | completed | Phase 1 | 3 | City of Hope Medical CenterOTHER | 1 | Feb 12, 2021 | clinicaltrials |
| NCT00489203 | Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer | completed | Phase 2 | 140 | Fred Hutchinson Cancer CenterOTHER | 1 | Feb 3, 2021 | clinicaltrials |
| NCT03755947 | Ibrutinib, Obinutuzumab and Venetoclax for Patients With Chronic Lymphocytic Leukemia | completed | Phase 2 | 3 | Grupo Cooperativo de Hemopatías MalignasOTHER | 1 | Feb 2, 2021 | clinicaltrials |
| NCT01930162 | Safety and Tolerability of HSC835 in Patients With Hematological Malignancies Undergoing Single Umbilical Cord Blood Transplant(UCBT) | completed | Phase 2 | 9 | Novartis PharmaceuticalsINDUSTRY | 1 | Jan 5, 2021 | clinicaltrials |
| NCT01474681 | Safety and Tolerability of HSC835 in Patients With Hematological Malignancies | completed | Phase 1 / Phase 2 | 27 | Novartis PharmaceuticalsINDUSTRY | 1 | Dec 30, 2020 | clinicaltrials |
| NCT02181478 | Intra-Osseous Co-Transplant of UCB and hMSC | completed | Early Phase 1 | 6 | Case Comprehensive Cancer CenterOTHER | 1 | Dec 4, 2020 | clinicaltrials |
| NCT02900716 | Safety Study of BTK Inhibitor, DTRMWXHS-12, Used Singly or in Combination, in CLL and B-cell Lymphomas | completed | Phase 1 | 48 | Zhejiang DTRM BiopharmaINDUSTRY | 1 | Nov 27, 2020 | clinicaltrials |
Data updated 23 days agoSource updated Feb 21, 2022source: clinicaltrials