Benign Head and Neck Neoplasm — Variants & evidence

Benign Head and Neck Neoplasm — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

2 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items (2 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CTNNB1 I35T + FBXW11 F517SFBXW11 CTNNB11
(diagnostic)	Basal Cell AdenomaALIAS	Diagnostic	B	Supports Positive	4	submitted	EID12637 A comprehensive molecular profiling (whole exome and whole transcriptome sequencing) determined that CTNNB1 I35T and FBXW11 F517S missense mutations were mutually exclusive and collectively account fo… (full text at CIViC) PMID 40389436 · Wong et al., 2025 · Open in CIViC	civic
NF2 Mutation1
Everolimus	Vestibular SchwannomaALIAS	Predictive	B	Supports N/A	3	rejected	EID1671 Ten patients with Neurofibromatosis 2 were enrolled for treatment with Everolimus. At 12 months, no patients had reduction in tumor volume >20%, however, five patients had stable disease with a reduc… (full text at CIViC) PMID 25567352 · Goutagny et al., 2015 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.