B Lymphoblastic Leukemia/Lymphoma with t(5;14)(q31.1;q32.3); IL3-IGH

B Lymphoblastic Leukemia/Lymphoma with t(5;14)(q31.1;q32.3); IL3-IGH — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
IL3 Fusion3
(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID12243 In this 2019 study, the authors included 8 patients with B-ALL presenting with t(5;14)(q31;q32) and reviewed another 16 patients from the literature. The median age at onset was 14.3 years (range of 4… (full text at CIViC) PMID 31921638 · Fournier et al., 2019 · Open in CIViC	civic
〃	Diagnostic	C	Supports Positive	4	accepted	EID12244 In this 2021 study the authors include four B-ALL cases with an IGH::IL3 gene fusion that initially were unable to be fully characterized by conventional methods. Patients' ages ranged from 6 to 19 ye… (full text at CIViC) PMID 33991782 · Guenzel et al., 2021 · Open in CIViC	civic
〃	Diagnostic	C	Supports Positive	2	accepted	EID12245 In this 1989 study the authors analyzed the bone marrow aspirate from a B-ALL patient presenting with eosinophilia in the peripheral blood and found to have the t(5;14)(q31;q32) chromosomal translocat… (full text at CIViC) PMID 2499362 · Grimaldi et al., 1989 · Open in CIViC	civic

Data updated 17 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.