B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1 — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RUNX1 Fusion4
(diagnostic)	Diagnostic	A	Supports Positive	5	accepted	EID8599 ETV6-RUNX1 rearranged leukemia is a well established diagnostic entity in the WHO classification of leukemia. It is designated as B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUN… (full text at CIViC) PMID 27069254 · Arber et al., 2016 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12293 In this study, the authors investigated the role of the ETV6::RUNX1 fusion in the diagnosis of B-lymphoblastic leukemia/lymphoma. B-ALL is a heterogeneous disease, and identifying cytogenetic abnormal… (full text at CIViC) PMID 9226156 · Borkhardt et al., 1997 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12375 In this study, the authors investigated the t(12;21)(p13;q22) in pediatric acute lymphoblastic leukemia (ALL). The t(12;21) is typically not visible by karyotype analysis and is rarely detected by con… (full text at CIViC) PMID 8609706 · Shurtleff et al., 1995 · Open in CIViC	civic
Not Applicable	Predictive	B	Supports Adverse Response	4	accepted	EID12374 In this study, the authors characterized the TEL (currently ETV6)::AML1 (currently RUNX1) gene fusion in B-lymphoblastic leukemia (B-ALL) with the t(12;21)(p12;q22) using cytogenetic and molecular met… (full text at CIViC) PMID 7780150 · Romana et al., 1995 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.