B Acute Lymphoblastic Leukemia with DUX4 Rearrangement — Variants & evidence

B Acute Lymphoblastic Leukemia with DUX4 Rearrangement — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
DUX4 Fusion + DUX4 Fusion1
(diagnostic)	Diagnostic	B	Supports Positive	4	submitted	EID11523 Integrated genomic analysis of was performed for 1,988 childhood and adult B-ALL cases. 106 cases (5.3%) showed DUX4 rearrangements, commonly with the IGH region. These cases were characterized by a u… (full text at CIViC) PMID 30643249 · Gu et al., 2019 · Open in CIViC	civic
DUX4 Fusion4
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12248 This study identifies DUX4 rearrangements, specifically IGH::DUX4 fusions, as diagnostic markers for a distinct molecular subtype of Philadelphia chromosome-negative (Ph−) B-lymphoblastic leukemia/lym… (full text at CIViC) PMID 27019113 · Yasuda et al., 2016 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12249 This study highlights the diagnostic significance of DUX4 gene rearrangements in a distinct molecular subtype of B-lymphoblastic leukemia/lymphoma (B-ALL). Among 1,913 B-ALL cases, including 1,347 chi… (full text at CIViC) PMID 27776115 · Zhang et al., 2016 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12250 In this study, the authors analyzed the fusion gene landscape in pediatric B-lymphoblastic leukemia (B-ALL) across 195 cases using RNA sequencing. Fusion genes were identified in 127 cases (65%), incl…

Data updated 24 minutes agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.