VEGFA Overexpression

CI-VAR-00003187Explore in graph →CIViC 2585

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 5 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Glioblastoma1
VEGFA Overexpression	Bevacizumab	Predictive	B	Supports Sensitivity Response	3	submitted	EID7013 We found that high VEGF expression (mean positive area > 5,000 pixels/×400 field) was associated with increased likelihood of achieving radiographic response (P = .024; Table 2). PMID 18182667 · Sathornsumetee et al., 2008 · Open in CIViC	civic
Malignant Breast Neoplasm1
VEGFA Overexpression	Bevacizumab	Predictive	B	Supports Sensitivity Response	3	submitted	EID9229 A meta analysis and systematic review of three trials with a total of 3748 breast cancer patients was undertaken to determine if VEGF-A plasma levels affected patient outcomes in response to bevacizum… (full text at CIViC) PMID 25947646 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Gastric Neoplasm1
VEGFA Overexpression	Bevacizumab	Predictive	B	Supports Sensitivity Response	2	submitted	EID7216 Patients with high baseline plasma VEGF-A levels showed a trend toward improved overall survival (hazard ratio [HR], 0.72; 95% CI, 0.57 to 0.93) versus patients with low VEGF-A levels (HR, 1.01; 95% C… (full text at CIViC) PMID 22565005 · Van Cutsem et al., 2012 · Open in CIViC	civic

Malignant Ovarian Neoplasm1
VEGFA Overexpression	Bevacizumab + ErlotinibCombination	Predictive	B	Supports Resistance	2	submitted	EID7237 This phase II trial evaluated the efficacy of bevacizumab+erlotinib in 40 platinum-resistant ovarian cancer patients. No evidence was found associating VEGFR-1 expression and any clinical parameters.… (full text at CIViC) PMID 21041183 · Chambers et al., 2010 · Open in CIViC	civic

Unmapped disease1unmapped disease
TP53 Mutation AND VEGFA Overexpression	(functional)	Functional	B	Supports Neomorphic	3	submitted	EID11727 This study investigates the relation between TP53 mutation status and VEGFA expression by analyzing data from 7,525 distinct tumor samples sourced from the TCGA database. The findings reveal a signifi… (full text at CIViC) PMID 31564192 · Li et al., 2020 · Open in CIViC	civic