TERT RS2736100

CI-VAR-00003943Explore in graph →NP_001180305.1:p.=NM_001193376.1:c.1574-3777G>TClinVar 375480 CIViC 421 rs2736100

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Brain Glioma1unmapped disease
TERT RS2736100	(predisposing)	Predisposing	B	Supports Predisposition	2	accepted	EID980 Meta-analysis of 10 studies (9,411 patients, 13,708 controls) showed that TERT polymorphisms (rs2736100) were associated with an increased glioma risk (RR=1.28, 95% CI 1.23-1.33). PMID 26765760 · Yuan et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
375480	Benign	criteria provided, single submitter	1	Chronic osteomyelitis; Chronic obstructive pulmonary disease; Interstitial lung disease 2; Combined pulmonary fibrosis-emphysema syndrome; Dyskeratosis congenita, autosomal dominant 2; Idiopathic Pulmonary Fibrosis; Susceptibility to severe coronavirus disease (COVID-19)	germline	3	Feb 04, 2026