TBXT Gain

CI-VAR-00001858Explore in graph →CIViC 4424

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chordoma2
TBXT Gain	(oncogenic)	Oncogenic	D	Supports Oncogenicity	1	submitted	EID11174 Knockdown of TBXT in the U-CH1 chordoma cell line with polysomy of chromosome 6 decreased proliferation and induced a senescence-like phenotype. PMID 21171078 · Presneau et al., 2011 · Open in CIViC	civic
TBXT Gain	(oncogenic)	Oncogenic	D	Supports Oncogenicity	1	submitted	EID11175 Knockdown of TBXT in the U-CH1 chordoma cell line with polysomy of chromosome 6 decreased proliferation and induced a senescence-like phenotype. PMID 21171078 · Presneau et al., 2011 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.