Gene

TBXT

T-box transcription factor T

Curated evidence

Clinical evidence (5)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TBXT Amplification1
(oncogenic)	Chordoma	Oncogenic	D	Supports Oncogenicity	1	submitted	EID11173 shRNA knockdown of TBXT in the JHC7 chordoma cell line with TBXT amplification resulted in differentiation and growth arrest. PMID 21699479 · Hsu et al., 2011 · Open in CIViC	civic
TBXT Expression2
(diagnostic)	Poorly Differentiated Chordoma	Diagnostic	B	Supports Positive	2	submitted	EID11172 All chordomas including 14 conventional chordomas and 7 poorly differentiated chordomas exhibited nuclear expression of brachyury (TBXT) by IHC whereas only 2 of 30 atypical teratoid/rhabdoid tumors w… (full text at CIViC) PMID 27067307 · Hasselblatt et al., 2016 · Open in CIViC

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

Data not yet available

No publication linked to this gene yet.