Variant · Snv

RET V804L

CI-VAR-00004643Explore in graph →NP_066124.1:p.Val804LeuNM_020975.6:c.2410G>TClinVar 13946 CIViC 1688 rs79658334

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chronic Myeloid Leukemia, BCR-ABL1 Positive1
KIF5B::RET Fusion AND RET V804L	Dasatinib	Predictive	D	Supports Resistance	2	submitted	EID7515 In an in vitro kinase study, the recombinant RET V804L mutant kinase demonstrated resistance to dasatinib treatment at concentrations of 1μM and 10μM (activity %: 101 and 91) when compared to wild typ… (full text at CIViC) PMID 19039322 · Remsing Rix et al., 2009 · Open in CIViC	civic
Lung Non-Small Cell Carcinoma1
KIF5B::RET Fusion AND RET V804L	Cabozantinib	Predictive	D	Does Not Support Resistance	3	submitted	EID4851 We established inducible KIF5B-RET transgenic mice and KIF5B-RET-dependent cell lines for preclinical modeling of KIF5B-RET-associated lung adenocarcinoma. By culturing cells with increasing concentra…

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
13946	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Familial medullary thyroid carcinoma; Multiple endocrine neoplasia, type 2; Multiple endocrine neoplasia; Hereditary cancer-predisposing syndrome; Multiple endocrine neoplasia type 2A; Multiple endocrine neoplasia type 2B; Hirschsprung disease, susceptibility to, 1; Pheochromocytoma; RET-related disorder	germline	20