RAD51D R186*

CI-VAR-00003742Explore in graph →ClinVar 30285 CIViC 471 rs387906843

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Breast Neoplasm1
RAD51D R186*	(predisposing)	Predisposing	C	N/A N/A	2	accepted	EID1111 A healthy, 36-year-old woman presented with a palpable right breast mass upon biopsy determined to be high-grade, triple negative invasive ductal carcinoma. Her family history was notable for multiple… (full text at CIViC) PMID 25445424 · Baker et al., 2015 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
30285	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Breast-ovarian cancer, familial, susceptibility to, 4; Hereditary cancer-predisposing syndrome; Hereditary breast ovarian cancer syndrome; Breast and/or ovarian cancer; Malignant tumor of breast; Ovarian neoplasm; Inherited breast cancer and ovarian cancer; Inherited ovarian cancer (without breast cancer); Polycystic kidney disease 2; RAD51D-related disorder