Variant · Snv

PDGFRA T674I

CI-VAR-00004335Explore in graph →NP_006197.1:p.Thr674IleNM_006206.5:c.2021C>TClinVar 13550 CIViC 577 rs121908587

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Myeloid/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Gene Fusions4
FIP1L1::PDGFRA Fusion AND PDGFRA T674I	Dasatinib	Predictive	D	Supports Resistance	2	submitted	EID4420 In an in vitro study, a Ba/F3 cell line stably expressing the T674I mutation in the PDGFRA portion of the FIPL1-PDGFRA fusion protein was found to have reduced sensitivity to dasatinib treatment (IC50… (full text at CIViC) PMID 19212337 · Lierman et al., 2009 · Open in CIViC	civic
FIP1L1::PDGFRA Fusion AND PDGFRA T674I	Imatinib	Predictive	C	Supports Resistance	2	accepted	EID1446 A patient treated with imatinib for a FIP1L1-PDGFRA mutation relapsed during treatment. A T674I mutation in the PDGFRA split kinase domain was hypothesized to confer resistance, due to the strong evid… (full text at CIViC) PMID 12660384 · Cools et al., 2003 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
13550	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Hypereosinophilic syndrome, idiopathic, resistant to imatinib; Gastrointestinal stromal tumor; Hereditary cancer-predisposing syndrome	germline	3	Jul 31, 2025	clinvar