MET Splice Site (c.3028+1G>T)

CI-VAR-00004203Explore in graph →NM_000245.4:c.3028+1G>TClinVar 225227 CIViC 4374 rs869320707

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Lung Neoplasm1
MET Splice Site (c.3028+1G>T)	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID11221 A homozygous splice site point mutation at the donor site of Met Exon 14 (G>T at +1 position; Figure 1A, and Figure S1a) was identified in the H596 lung cancer cell line. RT-PCR of RNA demonstrated sk… (full text at CIViC) PMID 16397241 · Kong-Beltran et al., 2006 · Open in CIViC	civic
Unmapped disease2unmapped disease
MET Exon 14 Skipping Mutation AND MET Splice Site (c.3028+1G>T)	(functional)	Functional	B	Supports Gain Of Function	3	submitted	EID12839 1141 patients with lung cancer were analyzed using NGS, to which MET exon 14 mutations were found in 28 (3.0%) of them. Of the 28, 24 samples had RNA available for qRT-PCR for MET splicing. 23/24 (96%… (full text at CIViC)

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
225227	Uncertain significance	criteria provided, single submitter	1	Osteofibrous dysplasia; Renal cell carcinoma	germline	3	Aug 13, 2025	clinvar