MET M1250T

CI-VAR-00002559Explore in graph →NP_000236.2:p.Met1250ThrNM_000245.4:c.3749T>CClinVar 376126 CIViC 3372 rs121913245

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
MET M1250T	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID9405 MET mutations found in papillary renal carcinomas were introduced into a chimeric construct composed of NGF and the intracellular portion of MET, and these were expressed in NIH3T3 cells. Expression o… (full text at CIViC) PMID 9826715 · Jeffers et al., 1998 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376126	Likely pathogenic	criteria provided, single submitter	1	Hereditary cancer-predisposing syndrome; Embryonal rhabdomyosarcoma	germline/somatic	2	Feb 28, 2024	clinvar