MAPK1 E322K

CI-VAR-00000723Explore in graph →NP_002736.3:p.Glu322LysNM_002745.4:c.964G>AClinVar 376450 CIViC 320 rs1057519911

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Head and Neck Squamous Cell Carcinoma2
MAPK1 E322K	Erlotinib	Predictive	C	Supports Sensitivity Response	4	accepted	EID791 Case report of a patient with stage IVA HNSCC with near-complete histologic response after 13 days of neoadjuvant erlotinib. Whole-exome sequencing of the pre-treatment tumor revealed a MAPK1 E322K mu… (full text at CIViC) PMID 26181029 · Van Allen et al., 2015 · Open in CIViC	civic
MAPK1 E322K	Erlotinib	Predictive	D	Supports Sensitivity Response	—	submitted	EID4797 In an in vitro study, a HSC-6 cell line expressing MAPK1 E322K mutation was associated with sensitivity to erlotinib treatment, compared to Cal33 cells expressing wild-type MAPK1. Sensitivity was dete… (full text at CIViC) PMID 27004400 · Wen et al., 2016 · Open in CIViC

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376450	-	-	—	Neoplasm	somatic	1	—	clinvar

Malignant Neoplasm1
MAPK1 E322K	(oncogenic)	Oncogenic	D	Supports Oncogenicity	4	submitted	EID12995 MAPK1 (ERK2) p.Glu322Lys (NM_002745.5:c.964G>A) rescues the anti-proliferative effects of trametinib (MEK inhibitor) in A375 cells (6 replicates). PMID 27760319 · Brenan et al., 2016 · Open in CIViC	civic