NTRK1 Fusion

CI-VAR-00001525Explore in graph →CIViC 5507

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma1
LRRC71::NTRK1 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID13058 Xu et al. retrospectively analyzed paired pre- and post-EGFR tyrosine kinase inhibitor samples from 3,873 patients with EGFR-mutant lung adenocarcinoma and identified an acquired LRRC71::NTRK1 fusion … (full text at CIViC) PMID 31372039 · Xu et al., 2019 · Open in CIViC	civic
Lung Squamous Cell Carcinoma1
LRRC71::NTRK1 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID13048 A retrospective study of tumors sequenced through the Veterans Health Administration National Precision Oncology Program identified NTRK rearrangements in 25 of 22,450 solid tumors. Twelve patients wi… (full text at CIViC) PMID 36926986 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Uterine Corpus Endometrial Carcinoma1unmapped disease
LRRC71::NTRK1 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID13057 Hartmaier et al. performed targeted hybrid-capture next-generation sequencing of 18,004 adult solid tumors and identified a novel LRRC71::NTRK1 fusion in one uterine corpus endometrial carcinoma. The … (full text at CIViC) PMID 28235761 · Hartmaier et al., 2017 · Open in CIViC	civic