KRAS Q61R

CI-VAR-00003574Explore in graph →NP_004976.2:p.Gln61ArgNM_004985.4:c.182A>GClinVar 45115 CIViC 909 rs121913240

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm3
KRAS Q61R	Cetuximab	Predictive	B	Supports Resistance	3	submitted	EID2229 In irinotecan-resistant metastatic colorectal cancer patients who had been treated with cetuximab and irinotecan, KRAS mutations in codon 61 or 146 were associated with shorter progression-free surviv… (full text at CIViC) PMID 19603018 · Loupakis et al., 2009 · Open in CIViC	civic
KRAS Q61R	Cetuximab	Predictive	C	Supports Resistance	—	submitted	EID3869 In a retrospective study of 138 metastatic irinotecan-refractory, colorectal cancer patients, patients with a KRAS codon 61 or 146 mutation (8/68) treated with cetuximab plus chemotherapy were associa… (full text at CIViC) PMID 19603018 · Loupakis et al., 2009 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
45115	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Noonan syndrome; RASopathy; Noonan syndrome and Noonan-related syndrome; Lung cancer; Neoplasm; Pilocytic astrocytoma	germline/somatic	6	Feb 03, 2021	clinvar